Synergistic impact of 25-hydroxyvitamin D concentrations and physical activity on delaying aging
Liu C, Hua L, Xin Z
Redox biology · 67 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2024-05-10 · Redox Biol · vol. 73 · p. 103188
- Publisher
- Elsevier BV
- Cited
- 68 citations · more than 100% of similar papers · 19.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 36 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Vitamin D Research Studies · Health, Environment, Cognitive Aging · Nutritional Studies and Diet
- Keywords
- Vitamin D and neurology, Gerontology, Physical activity, Medicine, Endocrinology, Physical medicine and rehabilitation
- MeSH
- humans, vitamin d, exercise, nutrition surveys, aging, adult, aged, middle aged, female, male
3 authors
From CN
- Chang LiuBeijing Tongren Hospital; Capital Medical University
- Lin Hua · correspondingCapital Medical University
- Xin Zhong · correspondingBeijing Tongren Hospital; Capital Medical University
Abstract
Objective
Our study aims to examine the independent and combined associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations and physical activity (PA) status with phenotypic age (PhenoAge).
Method
The analysis included 18,738 participants from the NHANES 2007-2010 & 2015-2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as the residuals from regressing PhenoAge on chronological age. Weighted multivariable logistic regression models were used to analysis the relationship between 25(OH)D and PA with PhenoAgeAccel. Population attributable fraction (PAF) was used to estimate the proportion of PhenoAgeAccel which could be avoided if exposure were eliminated.
Results
The multivariate-adjusted OR (95%CI) for PhenoAgeAccel with high 25(OH)D and adequate PA were 0.657 (0.549,0.787) (p < 0.001) for all, 0.663 (0.538,0.818) (p < 0.001) for participants whose age ≤65years old. Furthermore, there was multiplicative interaction between 25(OH)D and PA in age ≤65 years old group (0.729 (0.542,0.979), p = 0.036). High 25(OH)D level and adequate PA reduced the risk of PhenoAgeAccel by 14.3 % and 14.2 %, respectively. Notably, 30.7 % decrease was attributable to both high 25(OH)D level and engaging in adequate PA concurrently. Combining 25(OH)D above 80.4 nmol/l with PA decreased PhenoAge by 1.291 years (p < 0.001).
Conclusion
Higher 25(OH)D level was associated with lower risk of biological ageing. Combining 25(OH)D and PA demonstrated enhanced protective effects, especially in middle or young adults. These findings underscore the importance of outdoor PA in slowing down the aging process.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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