Funded in part by Isagenix International LLC
Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction
Mohr AE, Sweazea KL, Bowes DA, Jasbi P, Whisner CM, Sears DD, Krajmalnik-Brown R, Jin Y, Gu H, Klein-Seetharaman J, Arciero KM, Gumpricht E, Arciero PJ
Nature communications · 73 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Skidmore College
- Company
- Isagenix International LLC
- Authors
- At least one author declares a financial tie to industry
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-05-28 · Nat Commun · vol. 15 · issue 1 · p. 4155
- Publisher
- Nature Portfolio
- Cited
- 78 citations · more than 100% of similar papers · 17.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 118 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Gut microbiota and health · Diet and metabolism studies
- Keywords
- Intermittent fasting, Metabolomics, Overweight, Gut flora, Calorie restriction, Microbiome, Weight loss, Feces, Internal medicine, Dysbiosis, Calorie, Caloric theory, Obesity, Randomized controlled trial, Physiology, Weight management, Medicine, Biology, Bioinformatics, Immunology, Microbiology
- MeSH
- feces, humans, obesity, weight loss, dietary proteins, caloric restriction, fasting, body composition, adult, middle aged, female, male, metabolomics, metabolome, gastrointestinal microbiome, intermittent fasting
13 authors
From US
- Alex E. MohrArizona State University
- Karen L. SweazeaArizona State University
- Devin A. BowesArizona State University
- Paniz JasbiArizona State University
- Corrie Marie WhisnerArizona State University
- Dorothy D. SearsArizona State University
Abstract
The gut microbiome (GM) modulates body weight/composition and gastrointestinal functioning; therefore, approaches targeting resident gut microbes have attracted considerable interest. Intermittent fasting (IF) and protein pacing (P) regimens are effective in facilitating weight loss (WL) and enhancing body composition. However, the interrelationships between IF- and P-induced WL and the GM are unknown. The current randomized controlled study describes distinct fecal microbial and plasma metabolomic signatures between combined IF-P (n = 21) versus a heart-healthy, calorie-restricted (CR, n = 20) diet matched for overall energy intake in free-living human participants (women = 27; men = 14) with overweight/obesity for 8 weeks. Gut symptomatology improves and abundance of Christensenellaceae microbes and circulating cytokines and amino acid metabolites favoring fat oxidation increase with IF-P (p < 0.05), whereas metabolites associated with a longevity-related metabolic pathway increase with CR (p < 0.05). Differences indicate GM and metabolomic factors play a role in WL maintenance and body composition. This novel work provides insight into the GM and metabolomic profile of participants following an IF-P or CR diet and highlights important differences in microbial assembly associated with WL and body composition responsiveness. These data may inform future GM-focused precision nutrition recommendations using larger sample sizes of longer duration. Trial registration, March 6, 2020 (ClinicalTrials.gov as NCT04327141), based on a previous randomized intervention trial.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.