Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies
Hajhashemy Z, Shirani F, Askari G
Nutrition reviews · 7 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Isfahan University of Medical Sciences
- University or hospital
- Student Research Committee, Tabriz University of Medical Sciences
- University or hospital
- Student Research Committee
- University or hospital
- Isfahan University of Medical Sciences, Isfahan, Iran
- Grants
- Isfahan University of Medical Sciences (140274)
Based on 4 listed funder(s).
Publication
- Published
- 2024-05-29 · Nutr Rev · vol. 83 · issue 2 · pp. 217–229
- Publisher
- Oxford University Press
- Cited
- 10 citations · more than 71% of similar papers · 1.1× the field average
- References
- 48 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Magnesium Alloys: Properties and Applications
- Keywords
- Meta-analysis, Medicine, Depression (economics), Physiology, Magnesium, Internal medicine, Endocrinology, Gerontology, Chemistry
- MeSH
- humans, magnesium, diet, depression, dose-response relationship, drug, adult
3 authors
From IR
- Zahra HajhashemyIsfahan University of Medical Sciences
- Fatemeh ShiraniIsfahan University of Medical Sciences
- Gholamreza Askari · correspondingIsfahan University of Medical Sciences
Abstract
Context
The relation of magnesium (Mg) intake with depression was previously investigated by meta-analyses. However, due to limited data, a dose-response analysis was not performed.
Objective
Considering the recently published articles, a systematic review and dose-response meta-analysis was conducted to summarize the relation of dietary Mg intake with depression in adults.
Data sources
Medline (PubMed), ISI Web of Science, Scopus, and Google Scholar were comprehensively searched up to August 2023.
Data extraction
Observational studies that reported the relation of dietary Mg intake and depression in adults were included and their data were extracted.
Data analysis
A total of 63 214 participants from 10 cross-sectional and 3 cohort studies were included in the current study. Pooling 15 effect sizes from 12 studies (including 50 275 participants) revealed that individuals with the highest Mg intake had a 34% lower risk of depression, compared with those with the lowest Mg intake (RR: 0.66; 95% CI: 0.57, 0.78). Moreover, the linear dose-response analysis revealed that each 100-mg/d increment in Mg intake was associated with a 7% reduced risk of depression (RR: 0.93; 95% CI: 0.90, 0.96). Additionally, based on nonlinear dose-response analysis, increasing Mg intake from 170 to 370 mg/d was associated with a reduced risk of depression. Analyses were also conducted on 9 studies (49 558 participants) with representative populations, and similar results were found in the meta-analysis (RR: 0.71; 95% CI: 0.61, 0.83) and linear (RR: 0.93; 95% CI: 0.90, 0.96) and nonlinear dose-response analysis.
Conclusion
The current study shows an inverse dose-dependent association between dietary Mg intakes and risk of depression in both a general and representative population of adults in a dose-response manner.
Systematic review registration
PROSPERO registration no. CRD42024506570.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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