Funded in part by Eli Lilly and Company
Protective effects of sulforaphane against toxic substances and contaminants: A systematic review
Cascajosa-Lira A, Prieto AI, Pichardo S, Jos A, Cameán AM
Phytomedicine : international journal of phytotherapy and phytopharmacology · 16 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Industry funded
- Company
- Eli Lilly and Company
- Government
- Junta de Andalucía
- Grants
- Junta de Andalucía (P18-TP-2147)
Based on 2 listed funder(s).
Publication
- Published
- 2024-05-19 · Phytomedicine · vol. 130 · p. 155731
- Publisher
- Elsevier BV
- Cited
- 31 citations · more than 85% of similar papers · 1.6× the field average
- References
- 112 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Genomics, phytochemicals, and oxidative stress · Curcumin's Biomedical Applications · Retinoids in leukemia and cellular processes
- Keywords
- Sulforaphane, Environmental chemistry, Contamination, Chemistry, Toxicology, Biology, Biochemistry, Ecology
- MeSH
- animals, humans, brassica, isothiocyanates, sulfoxides, protective agents, oxidative stress, nf-e2-related factor 2
5 authors
From ES
- Antonio Cascajosa-LiraUniversidad de Sevilla
- Ana Isabel Prieto · correspondingUniversidad de Sevilla
- Silvia PichardoUniversidad de Sevilla
- Angeles M. JosUniversidad de Sevilla
- Ana Maria CameánUniversidad de Sevilla
Abstract
Background
Sulforaphane (SFN) is a dietary isothiocyanate, derived from glucoraphanin, present in cruciferous vegetables belonging to the Brassica genus. It is a biologically active phytochemical that acts as a nuclear factor erythroid 2-related factor 2 (Nrf2) inducer. Thus, it has been reported to have multiple protective functions including anticancer responses and protection against a toxic agent's action.
Purpose
The present work systematically reviewed and synthesised the protective properties of sulforaphane against a toxic agent. This review reveals the mechanism of the action of SFN in each organ or system.
Methods
The PRISMA guideline was followed in this sequence: researched literature, organised retrieved documents, abstracted relevant information, assessed study quality and bias, synthesised data, and prepared a comprehensive report. Searches were conducted on Science Direct and PubMed using the keywords "Sulforaphane" AND ("protective effects" OR "protection against").
Results
Reports showed that liver and the nervous system are the target organs on which attention was focused, and this might be due to the key role of oxidative stress in liver and neurodegenerative diseases. However, protective activities have also been demonstrated in the lungs, heart, immune system, kidneys, and endocrine system. SFN exerts its protective effects by activating the Nrf2 pathway, which enhances antioxidant defenses and reduces oxidative stress. It also suppresses inflammation by decreasing interleukin production. Moreover, SFN inhibits apoptosis by preventing caspase 3 cleavage and increasing Bcl2 levels. Overall, SFN demonstrates multifaceted mechanisms to counteract the adverse effects of toxic agents.
Conclusion
SFN has potential clinical applications as a chemoprotective agent. Nevertheless, more studies are necessary to set the safe doses of SFN in humans.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.