Total magnesium intake and risk of frailty in older women
Struijk EA, Fung TT, Bischoff-Ferrari HA, Willett WC, Lopez-Garcia E
Journal of cachexia, sarcopenia and muscle · 10 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Ministerio de Ciencia e Innovación
- Government
- National Institutes of Health
- Government
- Instituto de Salud Carlos III
- Government
- European Regional Development Fund
- Government
- National Cancer Institute
- Government
- European Social Fund
- Government
- Spanish Ministry of Science and Innovation
- Government
- ERDF/ESF (European Regional Development Fund/European Social Fund)
- Government
- NIH HHS
- Government
- NCI NIH HHS
- Government
- Instituto de Salud Carlos III, State Secretary of R+D+I of Spain
- Grants
- European Regional Development Fund (20/1040); National Cancer Institute (UM1 CA186107); Instituto de Salud Carlos III (FIS 20/1040); Instituto de Salud Carlos III (20/1040); Ministerio de Ciencia e Innovación (RYC2021‐031146‐I); Ministerio de Ciencia e Innovación (RYC2021); National Institutes of Health (UM1‐CA‐186107); National Institutes of Health (CA186107)
Based on 11 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-06-06 · J Cachexia Sarcopenia Muscle · vol. 15 · issue 4 · pp. 1275–1282
- Publisher
- Springer Science+Business Media
- Cited
- 12 citations · more than 89% of similar papers · 2.6× the field average
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Frailty in Older Adults · Nutrition and Health in Aging
- Keywords
- Medicine, Dietary Reference Intake, Proportional hazards model, Confidence interval, Magnesium, Relative risk, Lower risk, Magnesium deficiency (plants), Gerontology, Internal medicine, Nutrient
- MeSH
- humans, magnesium, risk factors, aged, middle aged, female, frailty
5 authors
From ES, US, CH
- Ellen A. Struijk · correspondingCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
- Teresa T. FungHarvard University; Simmons University
- Heike Annette Bischoff-FerrariUniversity of Zurich; Stadtspital Waid
- Walter Churchill WillettBrigham and Women's Hospital; Harvard University
- Esther López‐GarcíaMadrid Institute for Advanced Studies; IMDEA Food; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
Abstract
Background
An adequate magnesium intake might lower the risk of frailty through its role in muscle function.
Methods
We analysed data from 81 524 women aged ≥60 years participating in the Nurses' Health Study. Total magnesium intake was obtained from repeated food frequency questionnaires administered between 1984 and 2010 and self-reported information on supplementation. Frailty was defined as having at least three of the following five FRAIL scale criteria: fatigue, low strength, reduced aerobic capacity, having ≥5 chronic illnesses and weight loss ≥ 5%. The occurrence of frailty was assessed every 4 years from 1992 to 2018. Cox proportional hazards models adjusted for lifestyle factors, medication use and dietary factors were used to assess the association between magnesium intake and frailty.
Results
During a median follow-up of 16 years, we identified 15 477 incident cases of frailty. Women with a higher intake of total energy-adjusted magnesium had a decreased risk of frailty after adjustment for lifestyle factors, medication use and dietary factors. The relative risk (95% confidence interval) for Quintile 5 (Q5) versus Quintile 1 (Q1) was 0.88 (0.82, 0.94) (P-trend < 0.001). When only energy-adjusted magnesium from the diet was considered, the inverse association was stronger (Q5 vs. Q1: 0.68 [0.56, 0.82]; P-trend < 0.001). Those reaching the recommended daily allowance (RDA) of magnesium through diet had a 14% (9%, 19%) lower risk of frailty compared with those not meeting the RDA.
Conclusions
Increased intake of foods rich in magnesium was associated with a decreased risk of frailty.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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