Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial
Zhou X, Lin X, Yu J, Yang Y, Muzammel H, Amissi S, Schini-Kerth VB, Lei X, Jose PA, Yang J, Shi D
Nutrition journal · 21 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Chongqing Medical University
- Government
- Scientific Research Innovation Project for Postgraduate in Chongqing
- University or hospital
- Program of Chongqing Medical University for Youth Innovation in Future Medicine
- Grants
- National Natural Science Foundation of China (8210120502); National Natural Science Foundation of China (82100459); Chongqing Medical University (W0085)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-06-17 · Nutr J · vol. 23 · issue 1 · p. 65
- Publisher
- BioMed Central
- Cited
- 25 citations · more than 97% of similar papers · 5.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Enhanced Recovery After Surgery · Nutritional Studies and Diet
- Keywords
- Dash, DASH diet, Medicine, Blood pressure, Excretion, Randomized controlled trial, Internal medicine, Physical therapy
- MeSH
- humans, hypertension, treatment outcome, fasting, blood pressure, adult, middle aged, female, male, dietary approaches to stop hypertension
11 authors
From FR, CN, US
- Xiaoxin ZhouUniversité de Strasbourg; Chongqing Medical University
- Xiaoqian LinChongqing Medical University
- Jing YuChongqing Public Health Medical Center; Chongqing Medical University
- Yi YangChongqing Medical University
- Hira MuzammelUniversité de Strasbourg
- Said AmissiUniversité de Strasbourg
Abstract
Background
Time-restricted eating (TRE), a popular form of intermittent fasting, has shown benefits for improving metabolic diseases and cardiometabolic health. However, the effect of TRE in the regulation of blood pressure in primary hypertension remains unclear.
Methods
A 6-week randomized controlled trial was conducted, in which a total of 74 stage 1 primary hypertensive patients without high-risk were randomly assigned to Dietary Approaches to Stop Hypertension (DASH) group (n = 37) or DASH + TRE group (n = 37). Participants in the DASH + TRE group were instructed to consume their food within an 8-h window. Scientific research platform in We Chat application was used to track participants. The primary outcome was blood pressure. The secondary outcomes included body composition, cardiometabolic risk factors, inflammation-related parameters, urinary Na+ excretion, other clinical variables and safety outcomes.
Results
The reduction of systolic blood pressure and diastolic blood pressure were 5.595 ± 4.072 and 5.351 ± 5.643 mm Hg in the DASH group and 8.459 ± 4.260 and 9.459 ± 4.375 mm Hg in the DASH + TRE group. DASH + TRE group improved blood pressure diurnal rhythm. Subjects in DASH + TRE group had decreased extracellular water and increased urinary Na+ excretion. Furthermore, the decrease in blood pressure was associated with a reduction of extracellular water or increase in urinary Na+ excretion. In addition, safety outcomes such as nighttime hunger were also reported.
Conclusion
Our study demonstrated that 8-h TRE + DASH diet caused a greater decrease in blood pressure in stage 1 primary hypertensive patients than DASH diet. This study may provide novel insights into the benefits of lifestyle modification in the treatment of primary hypertension.
Trial registration
https://www.chictr.org.cn/ (ChiCTR2300069393, registered on March 15, 2023).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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