Broccoli Consumption and Risk of Cancer: An Updated Systematic Review and Meta-Analysis of Observational Studies
Baladia E, Moñino M, Pleguezuelos E, Russolillo G, Garnacho-Castaño MV
Nutrients · 8 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2024-05-23 · Nutrients · vol. 16 · issue 11 · p. 1583
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 12 citations · more than 86% of similar papers · 2.2× the field average
- References
- 104 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Morinda citrifolia extract uses · Genomics, phytochemicals, and oxidative stress · Bioactive Compounds and Antitumor Agents
- Keywords
- Meta-analysis, Medicine, Cochrane Library, Publication bias, Observational study, Subgroup analysis, Cohort study, Systematic review, MEDLINE, Relative risk, Cancer, Internal medicine, Study heterogeneity, Oncology, Confidence interval, Biology
- MeSH
- humans, brassica, neoplasms, diet, risk factors, case-control studies, female, observational studies as topic
5 authors
From ES
- Eduard Baladía
- Manuel MoñinoInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- Eulogio PleguezuelosHospital de Mataró
- Giuseppe Russolillo
- Manuel Vicente Garnacho‐Castaño · correspondingValencian International University; Universitat de Barcelona
Abstract
Background
The scientific literature has reported an inverse association between broccoli consumption and the risk of suffering from several types of cancer; however, the results were not entirely consistent across studies. A systematic review and meta-analysis of observational studies were conducted to determine the association between broccoli consumption and cancer risk with the aim of clarifying the beneficial biological effects of broccoli consumption on cancer.
Methods
PubMed/MEDLINE, Web of Science, Scopus, Cochrane Library (CENTRAL), and Epistemonikos databases were searched to identify all published papers that evaluate the impact of broccoli consumption on the risk of cancer. Citation chasing of included studies was conducted as a complementary search strategy. The risk of bias in individual studies was assessed using the Newcastle-Ottawa Scale. A random-effects model meta-analysis was employed to quantitatively synthesize results, with the I2 index used to assess heterogeneity.
Results
Twenty-three case-control studies (n = 12,929 cases and 18,363 controls; n = 31,292 individuals) and 12 cohort studies (n = 699,482 individuals) were included in the meta-analysis. The results suggest an inverse association between broccoli consumption and the risk of cancer both in case-control studies (OR: 0.64, 95% CI from 0.58 to 0.70, p p = 0.072, I2 = 30.49%-moderate heterogeneity; τ2 = 0.016) and cohort studies (RR: 0.89, 95% CI from 0.82 to 0.96, p = 0.003; Q = 13.51, p = 0.333, I2 = 11.21%-low heterogeneity; τ2 = 0.002). Subgroup analysis suggested a potential benefit of broccoli consumption in site-specific cancers only in case-control studies.
Conclusions
In summary, the findings indicate that individuals suffering from some type of cancer consumed less broccoli, suggesting a protective biological effect of broccoli on cancer. More studies, especially cohort studies, are necessary to clarify the possible beneficial effect of broccoli on several types of cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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