Funded in part by Specnova, Inc. (Boca Raton, FL, USA), Increnovo LLC, Specnova LLC
Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood
Leonard M, Dickerson B, Estes L, Gonzalez DE, Jenkins V, Johnson S, Xing D, Yoo C, Ko J, Purpura M, Jäger R, Faries M, Kephart W, Sowinski R, Rasmussen CJ, Kreider RB
Nutrients · 19 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Specnova, Inc. (Boca Raton, FL, USA)
- Company
- Increnovo LLC
- Company
- Specnova LLC
- Authors
- At least one author declares a financial tie to industry
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-06-08 · Nutrients · vol. 16 · issue 12 · p. 1813
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 43 citations · more than 100% of similar papers · 21.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 75 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection · Health, Education, and Aging
- Keywords
- Stroop effect, Mood, Vigilance (psychology), Medicine, Cognition, Audiology, Placebo, Profile of mood states, Effects of sleep deprivation on cognitive performance, Recall, Psychology, Clinical psychology, Psychiatry
- MeSH
- humans, plant leaves, plant roots, plant extracts, liposomes, double-blind method, affect, cognition, reaction time, dietary supplements, adolescent, adult, female, male, young adult, biomarkers
16 authors
From US
- Megan LeonardTexas A&M University
- Broderick L. DickersonTexas A&M University
- Landry EstesTexas A&M University
- Drew Edward GonzalezTexas A&M University
- Victoria M. JenkinsTexas A&M University
- Sarah E. JohnsonTexas A&M University
Abstract
Background
Ashwagandha has been reported to reduce stress and attenuate cognitive decline associated with inflammation and neurodegeneration in clinical populations. However, the effects as a potential nootropic nutrient in younger populations are unclear. This study examined the effects of liposomal ashwagandha supplementation on cognitive function, mood, and markers of health and safety in healthy young men and women.
Methods
59 men and women (22.7 ± 7 yrs., 74.9 ± 16 kg, 26.2 ± 5 BMI) fasted for 12 h, donated a fasting blood sample, and were administered the COMPASS cognitive function test battery (Word Recall, Word recognition, Choice Reaction Time Task, Picture Recognition, Digit Vigilance Task, Corsi Block test, Stroop test) and profile of mood states (POMS). In a randomized and double-blind manner, participants were administered 225 mg of a placebo (Gum Arabic) or ashwagandha (Withania somnifera) root and leaf extract coated with a liposomal covering. After 60-min, participants repeated cognitive assessments. Participants continued supplementation (225 mg/d) for 30 days and then returned to the lab to repeat the experiment. Data were analyzed using a general linear model (GLM) univariate analysis with repeated measures and pairwise comparisons of mean changes from baseline with 95% confidence intervals (CI).
Results
Ashwagandha supplementation improved acute and/or 30-day measures of Word Recall (correct and recalled attempts), Choice Reaction Time (targets identified), Picture Recognition ("yes" correct responses, correct and overall reaction time), Digit Vigilance (correct reaction time), Stroop Color-Word (congruent words identified, reaction time), and POMS (tension and fatigue) from baseline more consistently with several differences observed between groups.
Conclusion
Results support contentions that ashwagandha supplementation (225 mg) may improve some measures of memory, attention, vigilance, attention, and executive function while decreasing perceptions of tension and fatigue in younger healthy individuals. Retrospectively registered clinical trial ISRCTN58680760.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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