Isocaloric replacement of ultraprocessed foods was associated with greater weight loss in the POUNDS Lost trial
Yao Q, de Araujo CD, Juul F, Champagne CM, Bray GA, Sacks FM, Vadiveloo MK
Obesity (Silver Spring, Md.) · 7 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Center for Research Resources
- Government
- NHLBI NIH HHS
- Government
- NCRR NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (K01HL165104); National Heart, Lung, and Blood Institute (U01 HL-073286); National Center for Research Resources (M01 RR002635)
Based on 4 listed funder(s).
Publication
- Published
- 2024-06-27 · Obesity (Silver Spring) · vol. 32 · issue 7 · pp. 1281–1289
- Publisher
- Wiley
- Cited
- 8 citations · more than 92% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Open access (repository copy)
- Research areas
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Nutritional Studies and Diet
- Keywords
- Medicine, Waist, Overweight, Weight loss, Animal science, Obesity, Trunk, Circumference, Demography, Internal medicine, Biology, Mathematics
- MeSH
- humans, obesity, weight loss, body mass index, diet, reducing, prospective studies, energy intake, food handling, adult, middle aged, female, male, overweight, waist circumference, fast foods
7 authors
From US
- Qisi YaoUniversity of Rhode Island
- Carolina AraujoUniversity of Rhode Island
- Filippa JuulNew York University
- Catherine M. ChampagnePennington Biomedical Research Center
- George A. BrayPennington Biomedical Research Center
- Frank M. SacksBrigham and Women's Hospital; Harvard University
Abstract
Objective
Higher intake of ultraprocessed foods (UPFs) is associated with obesity. We examined whether replacing UPFs (NOVA 4) with minimally processed foods and culinary ingredients (NOVA 1 + 2) was associated with differential weight change in this secondary prospective analysis of the Preventing Overweight Using Novel Dietary Strategies (POUNDS) Lost trial.
Methods
We estimated percent energy intake (%kcal) from the four NOVA groups using 24-h dietary recalls in a subset of 356 participants. Multivariable-adjusted substitution models examined whether replacing %kcal from UPFs with NOVA 1 + 2 was associated with greater weight, body fat percentage, trunk fat, and waist circumference reduction at 6 months; changes in parameters were compared among NOVA 1 + 2 tertiles (T).
Results
Participants were on average 52.3 years of age, 85% White, 55% female, and 58.2% nonsmoking, with a mean BMI of 32.7 kg/m2. Replacing 10%kcal of UPFs with NOVA 1 + 2 was associated with greater 6-month weight (ß = 0.51, 95% CI: -0.93 to -0.09, p = 0.02), body fat percentage (ß = 2.7, 95% CI: -5.10 to -0.43, p = 0.02), and trunk fat reduction (ß = 3.9, 95% CI: -7.01 to -0.70, p = 0.02), but not waist circumference reduction. Participants in T3 (-8.33 kg) versus T1 (-5.32 kg) of NOVA 1 + 2 had greater weight loss (p < 0.001).
Conclusions
Isocaloric substitution of UPFs with NOVA 1 + 2 was associated with marginally greater weight loss under energy restriction. These modest findings support more research exploring the mechanisms linking UPFs with body weight regulation beyond energy intake.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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