A randomized controlled cross-over trial investigating the acute inflammatory and metabolic response after meals based on red meat, fatty fish, or soy protein: the postprandial inflammation in rheumatoid arthritis (PIRA) trial
Hulander E, Bärebring L, Winkvist A, Gjertsson I, Lindqvist HM
European journal of nutrition · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Vetenskapsrådet
- University or hospital
- Sahlgrenska Universitetssjukhuset
- University or hospital
- Göteborgs Universitet
- University or hospital
- University of Gothenburg
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-06-27 · Eur J Nutr · vol. 63 · issue 7 · pp. 2631–2642
- Publisher
- Springer Science+Business Media
- Cited
- 9 citations · more than 90% of similar papers · 2.6× the field average
- References
- 44 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Phytoestrogen effects and research · Fatty Acid Research and Health · Rheumatoid Arthritis Research and Therapies
- Keywords
- Postprandial, Very low-density lipoprotein, Rheumatoid arthritis, Red meat, Medicine, Crossover study, Meal, Blood lipids, Soy protein, Food science, Internal medicine, Lipoprotein, Cholesterol, Biology, Placebo, Insulin
- MeSH
- animals, fishes, humans, arthritis, rheumatoid, inflammation, lipids, triglycerides, soybean proteins, interleukin-6, cross-over studies, postprandial period, seafood, adult, aged, middle aged, female, male, meals, red meat
5 authors
From SE
- Erik Hulander · correspondingUniversity of Gothenburg
- Linnea BärebringUniversity of Gothenburg
- Anna WinkvistUniversity of Gothenburg
- Inger GjertssonUniversity of Gothenburg
- Helen M. LindqvistUniversity of Gothenburg
Abstract
Purpose
Rheumatoid Arthritis (RA) has a point prevalence of around 20 million people worldwide. Patients with RA often believe that food intake affects disease activity, and that intake of red meat aggravate symptoms. The main objective of the Postprandial Inflammation in Rheumatoid Arthritis (PIRA) trial was to assess whether postprandial inflammation and serum lipid profile are affected differently by a meal including red meat, fatty fish, or a soy protein (vegan) meal.
Methods
Using a randomized controlled crossover design, 25 patients were assigned to eat isocaloric hamburger meals consisting of red meat (60% beef, 40% pork), fatty fish (salmon), or soy protein for breakfast. Blood samples were taken before meals and at intervals up to 5 h postprandial. The analysis included the inflammation marker interleukin 6 (IL-6) and serum lipids.
Results
No significant differences in postprandial IL-6 or triglyceride concentrations were found between meals. However, the area under the curve of very low density lipoprotein (VLDL) particle counts, as well as VLDL-4-bound cholesterol, triglycerides, and phospholipids, was higher after the fatty fish compared to both red meat and soy protein.
Conclusion
Postprandial inflammation assessed by IL-6 did not indicate any acute negative effects of red meat intake compared to fatty fish- or soy protein in patients with RA. The fatty fish meal resulted in a higher number of VLDL-particles and more lipids in the form of small VLDL particles compared to the other protein sources.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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