Ultraprocessed Food Intake and Risk of Systemic Lupus Erythematosus Among Women Observed in the Nurses' Health Study Cohorts
Rossato S, Oakes EG, Barbhaiya M, Sparks JA, Malspeis S, Willett WC, Khandpur N, Costenbader KH
Arthritis care & research · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Cancer Institute
- Government
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Government
- NIH HHS
- Government
- NCI NIH HHS
- Government
- NIAMS NIH HHS
- Government
- NHLBI NIH HHS
- Grants
- National Cancer Institute (P01 CA087969); National Heart, Lung, and Blood Institute (R01-HL034594); National Cancer Institute (UM1 CA186107); National Institute of Arthritis and Musculoskeletal and Skin Diseases (K24‐AR‐066109); National Heart, Lung, and Blood Institute (R01-HL-088521); National Cancer Institute (U01 CA176726); National Cancer Institute (UM1 CA176726); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR 057327); National Cancer Institute (R01‐CA049449); National Cancer Institute (R01‐CA067262); National Institutes of Health (R01‐HL‐088521); National Institutes of Health (K24‐AR‐066109); National Institutes of Health (R01 HL034594); National Institutes of Health (U01-CA176726); National Institutes of Health (R01 AR 057327); National Institutes of Health (UM1‐CA‐186107); National Institutes of Health (P01-CA-087969); National Institutes of Health (R01‐CA‐049449); National Institutes of Health (R01-CA-067262)
Based on 8 listed funder(s).
Publication
- Published
- 2024-06-27 · Arthritis Care Res (Hoboken) · vol. 77 · issue 1 · pp. 50–60
- Publisher
- Wiley
- Cited
- 17 citations · more than 97% of similar papers · 6.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 62 works
- Access
- Free to read
- Research areas
- Consumer Attitudes and Food Labeling · Celiac Disease Research and Management · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Incidence (geometry), Prospective cohort study, Nurses' Health Study, Lupus erythematosus, Environmental health, Internal medicine, Immunology, Antibody
- MeSH
- humans, lupus erythematosus, systemic, diet, incidence, risk assessment, risk factors, prospective studies, food handling, adult, middle aged, nurses, united states, female, fast foods
8 authors
From US, NL
- Sinara Laurini RossatoHarvard University
- Emily G. OakesBrigham and Women's Hospital; Harvard University
- Medha BarbhaiyaHospital for Special Surgery; Cornell University
- Jeffrey A. SparksBrigham and Women's Hospital; Harvard University
- Susan MalspeisBrigham and Women's Hospital; Harvard University
- Walter Churchill WillettBrigham and Women's Hospital; Harvard University
Abstract
Objective
We assessed ultraprocessed food (UPF) intake and systemic lupus erythematosus (SLE) incidence within the prospective Nurses' Health Study (NHS) cohorts.
Methods
A total of 204,175 women were observed (NHS 1984-2016; NHSII 1991-2017). Semiquantitative food frequency questionnaires were completed every two to four years. UPF intake was determined as per the Nova classification. Nurses self-reported new doctor-diagnosed SLE, confirmed by medical records. Time-varying Cox regressions estimated hazard ratios (HRs; 95% confidence intervals [CIs]) for patients with incident SLE and SLE by anti-double-stranded DNA (dsDNA) antibody at diagnosis, according to cumulatively updated daily (a) UPF servings, (b) total intake (in grams and milliliters), and (c) percentage of total intake. Analyses adjusted for age, race, cohort, caloric and alcohol intakes, household income, smoking, body mass index (BMI), physical activity, menarchal age, and oral contraceptive use. We tested for interaction with BMI and examined UPF categories.
Results
Mean baseline age was ~50 years (NHS) and ~36 years (NHSII); 93% self-reported White race. A total of 212 patients with incident SLE were identified. SLE risk was higher in the third versus first UPF tertile (servings per day pooled multivariable [MV] HR 1.56, 95% CI 1.04-2.32; P = 0.03). Results were stronger for dsDNA antibody in patients with SLE (servings per day pooled MV HR 2.05, 95% CI 1.15-3.65; P = 0.01) and for absolute (servings or total) than percentage of total intake. Sugar-sweetened/artificially sweetened beverages were associated with SLE risk (third vs first tertile MV HR 1.45, 95% CI 1.01-2.09). No BMI interactions were observed.
Conclusion
Higher cumulative average daily UPF intake was associated with >50% increased SLE risk and with doubled risk for anti-dsDNA antibody in patients with SLE. Many deleterious effects on systemic inflammation and immunity are postulated.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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