The Effect of Dietary Nitrate on the Oral Microbiome and Salivary Biomarkers in Individuals with High Blood Pressure
du Toit L, Sundqvist ML, Redondo-Rio A, Brookes Z, Casas-Agustench P, Hickson M, Benavente A, Montagut G, Weitzberg E, Gabaldón T, Lundberg JO, Bescos R
The Journal of nutrition · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2024-07-16 · J Nutr · vol. 154 · issue 9 · pp. 2696–2706
- Publisher
- Elsevier BV
- Cited
- 27 citations · more than 98% of similar papers · 7.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Oral microbiology and periodontitis research · Gut microbiota and health · Salivary Gland Disorders and Functions
- Keywords
- Nitrate, Veillonella, Microbiome, Saliva, Actinomyces, Oral Microbiome, Bacteroides, Eubacterium, Prevotella, Food science, Prebiotic, Chemistry, Physiology, Fusobacteria, Streptococcus, Internal medicine, Microbiology, Biology, Biochemistry, Medicine, Firmicutes, Bacteria
- MeSH
- mouth, saliva, humans, vegetables, hypertension, nitrates, potassium compounds, diet, dietary supplements, adult, middle aged, female, male, microbiota, biomarkers
12 authors
From GB, SE, ES
- Lisa Du ToitUniversity of Plymouth
- Michaela L. SundqvistSwedish School of Sport and Health Sciences
- Álvaro Redondo-RíoBarcelona Supercomputing Center; Institute for Research in Biomedicine; Universitat Politècnica de Catalunya
- Zoë L.S. BrookesUniversity of Plymouth
- Patricia Casas‐AgustenchUniversity of Plymouth
- Mary Agnes HicksonUniversity of Plymouth
Abstract
Background
Green leafy vegetables (GLV) contain inorganic nitrate, an anion with potential prebiotic effects on the oral microbiome. However, it remains unclear whether GLV and pharmacological supplementation [potassium nitrate (PN)] with a nitrate salt induce similar effects on the oral microbiome.
Objectives
This study aimed to compare the effect of GLV with PN supplementation on the oral microbiome composition and salivary biomarkers in individuals with high blood pressure.
Methods
Seventy individuals were randomly allocated to 3 different groups to follow a 5-wk dietary intervention. Group 1 consumed 300 mg/d of nitrate in form of GLV. Group 2 consumed pills with 300 mg/d of PN and low-nitrate vegetables. Group 3 consumed pills with potassium chloride (placebo: PLAC) and low-nitrate vegetables. The oral microbiome composition and salivary biomarkers of oral health were analyzed before and after the dietary intervention.
Results
The GLV and PN groups showed similar microbial changes, probably nitrate-dependent, including an increase in the abundance of Neisseria, Capnocytophaga, Campylobacter species, and a decrease in Veillonella, Megasphaera, Actinomyces, and Eubacterium species after the treatment. Increased abundance of Rothia species, and reduced abundance of Streptococcus, Prevotella, Actinomyces, and Mogibacterium species were observed in the GLV group, which could be nitrate-independent. GLV and PN treatments increased salivary pH, but only GLV treatment showed an increase in the salivary buffering capacity and a reduction of lactate.
Conclusion
The combination of nitrate-dependent and nitrate-independent microbial changes in the GLV group has a stronger effect to potentially improve oral health biomarkers compared with PN.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.