Dietary Nitrosamines from Processed Meat Intake as Drivers of the Fecal Excretion of Nitrosocompounds
Ruiz-Saavedra S, Pietilä TK, Zapico A, de Los Reyes-Gavilán CG, Pajari AM, González S
Journal of agricultural and food chemistry · 10 citations
Review labels
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How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Gobierno del Principado de Asturias
- Government
- Ministerio de Ciencia e Innovación
- Government
- European Regional Development Fund
- Government
- Agencia Estatal de Investigación
- Government
- Ministerio de Ciencia e Innovaci?n
- Grants
- Agencia Estatal de Investigación (AEI//10.13039/501100011033/); Ministerio de Ciencia e Innovación (PID2022-140410OB-I00); European Regional Development Fund (MCIN/AEI/10); Agencia Estatal de Investigación (501100011033); Agencia Estatal de Investigación (10.13039/501100011033); Gobierno del Principado de Asturias (PA-23-BP22-034); Agencia Estatal de Investigación (MCIN/AEI/10.13039/501 100 011 033); Agencia Estatal de Investigación (13039); European Regional Development Fund (10.13039/501100011033); Agencia Estatal de Investigación (.13039/501100011033); European Regional Development Fund (13039/501100011033); Agencia Estatal de Investigación (10.13039); Agencia Estatal de Investigación (PID2022-140410OB-I00); European Regional Development Fund (501100011033); European Regional Development Fund (RTI2018); Agencia Estatal de Investigación (RTI2018-098288-B-I00); Gobierno del Principado de Asturias (2021-BP20-012); Agencia Estatal de Investigación (AEI/10); Ministerio de Ciencia e Innovación (RTI2018-098288-B-I00); Gobierno del Principado de Asturias (AYUD/2021/50981); European Regional Development Fund (MCIN/ AEI/ 10.13039/501100011033)
Based on 5 listed funder(s).
Publication
- Published
- 2024-07-29 · J Agric Food Chem · vol. 72 · issue 31 · pp. 17588–17598
- Publisher
- American Chemical Society
- Cited
- 13 citations · more than 91% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Water Treatment and Disinfection · Sulfur Compounds in Biology · Indoor Air Quality and Microbial Exposure
- Keywords
- Feces, Carcinogen, Chemistry, Food science, Excretion, Nitrosamine, Azoxymethane, Colorectal cancer, Urine, Xenobiotic, Biochemistry, Cancer, Internal medicine, Biology, Medicine, Microbiology, Enzyme
- MeSH
- feces, animals, humans, colorectal neoplasms, nitroso compounds, nitrosamines, carcinogens, diet, meat products, adult, aged, middle aged, female, male
6 authors
From ES, FI
- Sergio Ruiz-SaavedraInstituto de Productos Lácteos de Asturias; Instituto de Investigación Sanitaria del Principado de Asturias
- Tuulia Kreetta PietiläUniversity of Helsinki
- Aida ZapicoUniversidad de Oviedo; Instituto de Investigación Sanitaria del Principado de Asturias
- Clara G. de los Reyes‐GavilánInstituto de Productos Lácteos de Asturias; Instituto de Investigación Sanitaria del Principado de Asturias
- Anne‐Maria PajariUniversity of Helsinki
- Sónia González · correspondingUniversidad de Oviedo; Instituto de Investigación Sanitaria del Principado de Asturias
Abstract
Diet is one of the main exogenous sources of potentially carcinogenic nitrosamines (NAs) along with tobacco and cosmetics. Several factors can affect endogenous N-nitroso compounds (NOCs) formation and therefore the potential damage of the intestinal mucosa at initial colorectal cancer stages. To address this issue, 49 volunteers were recruited and classified according to histopathological analyses. Lifestyle and dietary information were registered after colonoscopy. The mutagenicity of fecal supernatants was assayed by a modified Ames test. Fecal heme-derived NOCs and total NOC concentrations were determined by selective denitrosation and chemiluminescence-based detection. Results revealed processed meats as the main source of dietary nitrites and NAs, identifying some of them as predictors of the fecal concentration of heme-derived and total NOCs. Furthermore, increased fecal NOC concentrations were found as the severity of colonic mucosal damage increased from the control to the adenocarcinoma group, these concentrations being strongly correlated with the intake of the NAs N-nitrosodimethylamine, N-nitrosopiperidine, and N-nitrosopyrrolidine. Higher fecal NOC concentrations were also noted in higher fecal mutagenicity samples. These results could contribute to a better understanding of the importance of modulating dietary derived xenobiotics as related with their impact on the intestinal environment and colonic mucosa damage.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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