"The effects of non-surgical periodontal treatment plus zinc and magnesium supplementation on oxidative stress and antioxidants enzymes in type 2 diabetes patients: a quasi-experimental study"
Alarcón-Moreno JC, Flores-Muñoz M, Blázquez-Morales MSL, García-Rivera ME, Rodríguez-Alba JC, Castro-López CR, Nachón-García FJ, Muñoz-Muñoz VH, Nachón-García MG
BMC oral health · 9 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Consejo Nacional de Ciencia y Tecnología
- University or hospital
- Universidad Veracruzana
- University or hospital
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-08-04 · BMC Oral Health · vol. 24 · issue 1 · p. 892
- Publisher
- BioMed Central
- Cited
- 8 citations · more than 89% of similar papers · 2.3× the field average
- References
- 52 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Oral microbiology and periodontitis research · Oral and gingival health research · Periodontal Regeneration and Treatments
- Keywords
- Medicine, Diabetes mellitus, Oxidative stress, Type 2 Diabetes Mellitus, Oral and maxillofacial surgery, Periodontal disease, Disease, Internal medicine, Type 2 diabetes, Dentistry, Gastroenterology, Endocrinology
- MeSH
- humans, periodontal diseases, diabetes mellitus, type 2, magnesium, zinc, magnesium oxide, gluconates, antioxidants, oxidative stress, dietary supplements, adult, middle aged, female, male
9 authors
From MX
- José Carlos Alarcón-MorenoUniversidad Veracruzana
- Mónica Flores‐MuñozUniversidad Veracruzana
- María Sobeida Leticia Blázquez-MoralesUniversidad Veracruzana
- Miguel Eric García-RiveraUniversidad Veracruzana
- Juan Carlos Rodríguez‐AlbaUniversidad Veracruzana
- Claudio Rafael Castro-LópezUniversidad Veracruzana
Abstract
Background
Periodontal Disease (PD) associated with Type 2 Diabetes Mellitus (T2DM) is a chronic condition that affects the oral cavity of people living with T2DM. The mechanisms of the interaction between type 2 Diabetes Mellitus and Periodontal diseases are complex and involve multiple pathophysiological pathways related to the systemic inflammatory process and oxidative stress. Non-surgical periodontal treatment (NSTP) is considered the standard for the management of this disease; however, patients with systemic conditions such as type 2 Diabetes Mellitus do not seem to respond adequately. For this reason, the use of complementary treatments has been suggested to support non-surgical periodontal treatment to reduce the clinical consequences of the disease and improve the systemic conditions of the patient. The use of zinc gluconate and magnesium oxide as an adjunct to non-surgical periodontal treatment and its effects on periodontal clinical features and oxidative stress in patients with Periodontal diseases -type 2 Diabetes Mellitus is poorly understood.
Methods
A quasi-experimental study was performed in patients with periodontal diseases associated with T2DM. Initially, 45 subjects who met the selection criteria were included. 19 were assigned to a control group [non-surgical periodontal treatment] and 20 to the experimental group (non-surgical periodontal treatment + 500 mg of magnesium oxide and 50 mg of zinc gluconate for oral supplementation for 30 days) and the data of 6 patients were eliminated. Sociodemographic characteristics, physiological factors, biochemical parameters, and clinical features of periodontal diseases were assessed.
Results
In this research a change in periodontal clinical characteristics was observed, which has been associated with disease remission. Additionally, a shift in MDA levels was presented for both groups. Furthermore, the supplementation group showed an increase in antioxidant enzymes when compared to the group that only received NSPT.
Conclusion
The use of Zinc gluconate and magnesium oxide can serve as a complementary treatment to non-surgical periodontal treatment, that supports the remission of PD as a result of regulation-reduction of oxidative biomarkers and increase in antioxidant enzymes activity.
Trial registration
https://www.isrctn.com ISRCTN 14,092,381. September 13º 2023. Retrospective Registration.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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