Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database
Liu H, Zhang K, Xiong L
Journal of health, population, and nutrition · 10 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2024-08-05 · J Health Popul Nutr · vol. 43 · issue 1 · p. 112
- Publisher
- BioMed Central
- Cited
- 10 citations · more than 86% of similar papers · 2.1× the field average
- References
- 47 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Rheumatoid Arthritis Research and Therapies
- Keywords
- Medicine, Hazard ratio, Rheumatoid arthritis, Internal medicine, Body mass index, Proportional hazards model, Confidence interval, Cause of death, Disease
- MeSH
- humans, arthritis, rheumatoid, magnesium, body mass index, diet, nutrition surveys, mortality, cause of death, proportional hazards models, databases, factual, adult, aged, middle aged, united states, female, male
3 authors
From CN
- Hantian LiuNanchang University
- Kui ZhangWest China Medical Center of Sichuan University
- Long Xiong · correspondingNanchang University; Second Affiliated Hospital of Nanchang University
Abstract
Background
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with all-cause mortality increasing globally. Dietary magnesium (Mg), an anti-inflammatory nutrient, has been proven to be associated with the all-cause mortality. The association of dietary Mg intake and all-cause mortality in RA patients remains unknown. The aim of this study was to assess the association between dietary Mg intake and all-cause mortality in RA patients.
Methods
RA patients were extracted from the NHANES 1999-2018, and followed for survival through December 31, 2019. Dietary Mg intake data were obtained from 24-h dietary recall interview. The association between dietary Mg intake and RA patients' all-cause mortality was explored based on weighted univariate and multivariate Cox proportional hazard models and described as absolute risk difference (ARD), hazard ratios (HRs) and 95% confidence intervals (CIs). This association was further explored in subgroup analyses based on different age, gender and body mass index (BMI).
Results
Totally 2,952 patients were included. Until 31 December 2019, a total of 825 deaths were documented. RA patients with higher dietary Mg intake had a 11.12% reduction of all-cause mortality (ARD=-11.12%; HR = 0.74, 95%CI: 0.56-0.99) in the fully adjusted model, especially in female (HR = 0.68, 95%CI: 0.47-0.98), aged 2 (HR = 0.62, 95%CI: 0.42-0.91).
Conclusion
RA patients who consumed adequate dietary Mg from diet as well as supplements may had a lower risk of all-cause mortality.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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