The Association between the Substitution of Red Meat with Legumes and the Risk of Primary Liver Cancer in the UK Biobank: A Cohort Study
Bock N, Langmann F, Johnston LW, Ibsen DB, Dahm CC
Nutrients · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- University or hospital
- Aarhus Universitets Forskningsfond
- University or hospital
- Steno Diabetes Center Aarhus
- University or hospital
- Steno Diabetes Center Aarhus (SDCA)
- University or hospital
- Aarhus University Research Foundation (AUFF)
- University or hospital
- the Steno Diabetes Center Aarhus
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-07-23 · Nutrients · vol. 16 · issue 15 · p. 2383
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 4 citations · more than 77% of similar papers · 1.0× the field average
- References
- 50 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease · Nutritional Studies and Diet
- Keywords
- Biobank, Cohort, Medicine, Cohort study, Environmental health, Cancer, Internal medicine, Oncology, Biotechnology, Bioinformatics, Biology
- MeSH
- humans, fabaceae, liver neoplasms, diet, proportional hazards models, risk factors, cohort studies, diet, vegetarian, adult, aged, middle aged, female, male, red meat, united kingdom, uk biobank
5 authors
From DK
- Natalie BockAarhus University
- Fie LangmannAarhus University
- Luke JohnstonSteno Diabetes Centers; Aarhus University; Aarhus University Hospital; Steno Diabetes Center Aarhus
- Daniel Borch IbsenSteno Diabetes Centers; Aarhus University; Aarhus University Hospital; Steno Diabetes Center Aarhus
- Christina Catherine Dahm · correspondingAarhus University
Abstract
Primary liver cancer is globally on the rise, partially due to poor diets and sedentary lifestyles. Shifting to more plant-based diets may lower the risk. We aimed to estimate the effect of replacing total red meat, unprocessed red meat and processed red meat with legumes on primary liver cancer in a free-living population. We analyzed data from 126,744 UK Biobank participants who completed ≥ two 24 h diet recalls. Baseline characteristics were collected from the initial assessment visit. Information on liver cancer diagnoses was collected via external linkage to inpatient hospital episodes or central cancer registries. Cox proportional hazards regression models were used to estimate the substitution of 15 g/day of legumes with 15 g/day of total red meat, unprocessed red meat or processed red meat on liver cancer risk, using the leave-one-out food substitution model. During a median follow-up time of 11.1 years, 173 participants developed liver cancer. In the fully adjusted models, no association was observed when substituting 15 g/day of legumes with total red meat (HR: 1.02 (95% CI 0.96-1.08)), unprocessed red meat (HR: 1.00 (95% CI 0.94-1.06)) or processed red meat (HR: 1.09 (95% CI 0.99-1.21)). Overall, little evidence of an association between replacing red meat with legumes and liver cancer was observed. Further research in other study populations with longer follow-up time is warranted.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.