Funded in part by Fundación Mapfre, MAPFRE Foundation, Ignacio H. de Larramendi, MAPFRE Foundation
Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation
Varillas-Delgado D
Nutrients · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Fundación Mapfre
- Company
- MAPFRE Foundation, Ignacio H. de Larramendi
- Company
- MAPFRE Foundation
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-08-01 · Nutrients · vol. 16 · issue 15 · p. 2511
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 18 citations · more than 97% of similar papers · 6.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 97 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Genetics and Physical Performance · Muscle metabolism and nutrition · Sports Performance and Training
- Keywords
- Creatine, Body mass index, Medicine, Internal medicine, Anthropometry, Endocrinology, Odds ratio, Athletes, Physical therapy
- MeSH
- muscle, skeletal, humans, athletic injuries, creatine, amp deaminase, peptidyl-dipeptidase a, actinin, body mass index, longitudinal studies, genotype, polymorphism, single nucleotide, soccer, dietary supplements, adult, male, creatine kinase, mm form, young adult, athletes
1 author
From ES
- David Varillas‐Delgado · correspondingUniversidad Francisco de Vitoria
Abstract
Background
In recent years, the study of creatine supplementation in professional athletes has been of great interest. However, the genetics involved in response to supplementation is unknown. The aim of this study was to analyse, for the first time, the relationship between muscle performance-related genes and the risk of an increased body mass index (BMI) and muscle mass and a decrease in fat mass in professional football players after creatine supplementation.
Methods
For this longitudinal study, one hundred and sixty-one men's professional football players were recruited. The polymorphisms ACE I/D, ACTN3 c.1729C>T, AMPD1 c.34C>T, CKM c.*800A>G, and MLCK (c.49C>T and c.37885C>A) were genotyped using Single-Nucleotide Primer Extension (SNPE). To assess the combined impact of these six polymorphisms, a total genotype score (TGS) was calculated. The creatine supplementation protocol consisted of 20 g/day of creatine monohydrate for 5 days (loading dose) and 3-5 g/day for 7 weeks (maintenance dose). Anthropometric characteristics (body mass index (BMI), fat, and muscle mass) were recorded before and after the creatine supplementation protocol. Characteristics of non-contact muscle injuries during the 2022/2023 season were classified according to a consensus statement for injury recording. The results showed that the allelic frequencies of ACE and AMPD1 differed between responders and non-responders in muscle mass increase (all p p = 0.001) for muscle mass increase. By contrast, those with a TGS below 54.16 a.u. had an OR of 9.385 (95%CI: 4.535-19.425; p < 0.001) for suffering non-contact muscle injuries during the season.
Conclusions
The increase in BMI and muscle mass in response to creatine supplementation in professional football players was influenced by a TGS derived from the combination of favourable genotypes linked to muscle performance. The CC genotype and C allele of AMPD1 were particularly associated with a higher likelihood of muscle mass increase under creatine supplementation in this group of professional football players.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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