Axial Length Shortening after Combined Repeated Low-Level Red-Light Therapy in Poor Responders of Orthokeratology in Myopic Children
Yu M, Tang X, Jiang J, Zhou F, Wang L, Xiang C, Hu Y, Yang X
Journal of ophthalmology · 9 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Guangdong Science and Technology Department
- Government
- Science and Technology Planning Project of Guangdong Province
- Government
- Guangdong Provincial Department of Science and Technology
- Grants
- Guangdong Science and Technology Department (2023A1111120013); National Natural Science Foundation of China (82371089); National Natural Science Foundation of China (30309010012226)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-01-01 · J Ophthalmol · vol. 2024 · issue 1 · p. 4133686
- Publisher
- Hindawi Publishing Corporation
- Cited
- 14 citations · more than 94% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 27 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Ocular Surface and Contact Lens
- Keywords
- Medicine, Orthokeratology, Red light, Optometry, Ophthalmology
8 authors
From CN, US
- Mengting YuSun Yat-sen University
- Xianghua TangSun Yat-sen University
- Jinyun JiangSun Yat-sen University
- Fengqi ZhouMayo Clinic; Mayo Clinic Health System
- Lili WangSun Yat-sen University
- Chuqi XiangSun Yat-sen University
Abstract
Purpose
To investigate the efficacy and safety of orthokeratology (ortho-k) and repeated low-level red-light (RLRL) therapy in treating poor responders of ortho-k in myopic children.
Methods
Study participants were 100 myopic children who completed two years of ortho-k treatment in a retrospective study. In the first year of ortho-k treatment (phase one), they experienced axial elongation of 0.30 mm or greater (defined as poor responders to ortho-k). Children were divided into two groups: the orthokeratology group (OK, n = 45) continued to receive ortho-k monotherapy and the combination group (OK-RLRL, n = 55) received RLRL in addition to ortho-k for the next year (phase two). Axial elongation over time between the groups was compared.
Results
The mean age, male-to-female ratio, axial length (AL), and axial elongation in phase one were comparable between OK and OK-RLRL groups (all P > 0.05). During phase two, significant AL shortening was observed in the OK-RLRL group compared with children in the OK group (-0.10 ± 0.16 mm vs 0.30 ± 0.19 mm, P β = -0.02), higher treatment compliance (β = -0.462), and AL change at 1 month (β = 1.263) were significantly associated with less AL elongation (all P < 0.05).
Conclusions
For poor responders of orthokeratology, RLRL could slow axial elongation in addition to the ortho-k treatment effect. Those who respond poorly to ortho-k with elder age might benefit more from combined therapy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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