Implications of food ultra-processing on cardiovascular risk considering plant origin foods: an analysis of the UK Biobank cohort
Rauber F, Laura da Costa Louzada M, Chang K, Huybrechts I, Gunter MJ, Monteiro CA, Vamos EP, Levy RB
The Lancet regional health. Europe · 30 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- World Health Organization
- Nonprofit
- World Cancer Research Fund International
- Nonprofit
- World Cancer Research Fund
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-06-13 · Lancet Reg Health Eur · vol. 43 · p. 100948
- Publisher
- Elsevier BV
- Cited
- 61 citations · more than 100% of similar papers · 23.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Agriculture Sustainability and Environmental Impact · Global Public Health Policies and Epidemiology
- Keywords
- Biobank, Cohort, Environmental health, Cohort study, Medicine, Risk analysis (engineering), Biology, Bioinformatics, Internal medicine
8 authors
From BR, VN, GB, FR
- Fernanda RauberUniversidade de São Paulo; General Department of Preventive Medicine
- Maria Laura da Costa LouzadaUniversidade de São Paulo
- Kiara ChangImperial College London
- Inge HuybrechtsCentre international de recherche sur le cancer
- Marc James GunterCentre international de recherche sur le cancer; Imperial College London
- Carlos Augusto MonteiroUniversidade de São Paulo
Abstract
Background
Comprehensive research evidence is lacking on the role of ultra-processed foods (UPF) in the relationship between the consumption of plant-sourced foods and their impact on cardiovascular disease (CVD) outcomes. This study aims to assess CVD risk associated with the dietary contribution of food groups that consider both plant or animal origin and food processing categories, within a large cohort of British adults.
Methods
Data from the UK Biobank participants (40-69 y) who completed at least two 24-h dietary recalls between 2009 and 2012 (n = 126,842; median follow-up: 9 y), with subsequent data linkage to hospital and mortality records, were used. Food groups were classified as either plant-sourced or non-plant/animal-sourced foods. These groups were further divided into non-UPF and UPF, and expressed as a percentage of total energy intake.
Findings
Every 10 percentage points increase in plant-sourced non-UPF consumption was associated with a 7% lower risk of CVD (95% CI 0.91-0.95) and a 13% lower risk of CVD mortality (0.80-0.94). Conversely, plant-sourced UPF consumption was associated with a 5% increased risk (1.03-1.07) and a 12% higher mortality (1.05-1.20). The contribution of all UPF was linked to higher CVD risk and mortality, and no evidence for an association between contribution of all plant-sourced foods and CVD incidence and mortality was observed.
Interpretation
The dietary contribution of plant-sourced non-UPF inversely linked to CVD risk, while plant-sourced UPF contribution showed a positive association. Recognizing the role of food processing is crucial for favourable CVD outcomes, even in plant-sourced diets.
Funding
World Cancer Research Fund.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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