Asian Low-Carbohydrate Diet with Increased Whole Egg Consumption Improves Metabolic Outcomes in Metabolic Syndrome: A 52-Week Intervention Study
Pinsawas B, Surawit A, Mongkolsucharitkul P, Pongkunakorn T, Suta S, Manosan T, Ophakas S, Pumeiam S, Sranacharoenpong K, Mayurasakorn K
The Journal of nutrition · 13 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Mahidol University
Based on 1 listed funder(s).
Publication
- Published
- 2024-09-07 · J Nutr · vol. 154 · issue 11 · pp. 3331–3345
- Publisher
- Elsevier BV
- Cited
- 18 citations · more than 95% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Diet and metabolism studies · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Keywords
- Metabolic syndrome, Carbohydrate, Food science, Medicine, Biology, Internal medicine, Physiology, Endocrinology, Obesity
- MeSH
- egg yolk, humans, insulin resistance, obesity, triglycerides, eggs, adult, middle aged, female, male, diet, carbohydrate-restricted, waist circumference, metabolic syndrome, diet, ketogenic
10 authors
From TH
- Bonggochpass PinsawasSiriraj Hospital; Mahidol University
- Apinya SurawitSiriraj Hospital; Mahidol University
- Pichanun MongkolsucharitkulSiriraj Hospital; Mahidol University
- Tanyaporn PongkunakornSiriraj Hospital; Mahidol University
- Sophida SutaSiriraj Hospital; Mahidol University
- Thamonwan ManosanSiriraj Hospital; Mahidol University
Abstract
Background
The low-carbohydrate-ketogenic diet, an effective strategy to address metabolic syndrome (MetS) and obesity has raised concerns about high-fat consumption on atherogenic lipoproteins.
Objective
The aim of this study was to compare the Asian ketogenic diet (AKD), which incorporates balanced protein and fat intake from Asian foods, with a balanced low-caloric diet (BLC) in individuals diagnosed with MetS.
Methods
A 52-wk randomized clinical trial included 3 parallel groups: AKD with increased whole egg intake [egg yolk Asian ketogenic diet (Yolk-AKD, n = 28)], yolk-free ketogenic diet with egg white supplementation [egg white Asian ketogenic diet (White-AKD, n = 26)], and BLC (n = 22). Primary outcomes were anthropometric and metabolic changes.
Results
The AKD groups achieved significant reductions in weight and waist circumference (P < 0.05). Compared with the BLC group, the AKD groups demonstrated significant improvements in insulin resistance at week 6 and in triglyceride concentrations at weeks 12 (Yolk-AKD) and 35 (White-AKD) (P < 0.05). The AKD groups experienced improvements in hormones associated with insulin sensitivity and appetite, whereas only the Yolk-AKD group had a significant decrease in inflammation-related hormones (P < 0.05). From weeks 35-52, the AKD maintained reductions in anthropometric measurements, blood pressure, improved glucose tolerance, enhanced lipid profiles, and better liver function compared with the BLC.
Conclusions
The AKD proved safe and effective, yielding various metabolic improvements in individuals with MetS compared with the BLC. Emphasizing a low-saturated fat diet while disregarding dietary cholesterol, this approach holds promise for MetS and obesity management. The inclusion of both White-AKD and Yolk-AKD groups allowed for a comprehensive assessment of the AKD's impact, elucidating the differential effects of whole egg consumption on metabolic outcomes. Further studies are warranted. This trial was registered at clinicaltrials.gov as NCT04608136.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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