In vitro endocrine and cardiometabolic toxicity associated with artificial turf materials
Siegel KR, Murray BR, Gearhart J, Kassotis CD
Environmental toxicology and pharmacology · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- Wayne State University
- Government
- National Institute of Environmental Health Sciences
- Government
- NIEHS NIH HHS
- Government
- NIEHS
- Grants
- Wayne State University (ES020957); National Institute of Environmental Health Sciences (P2C ES033423); National Institute of Environmental Health Sciences (P30ES020957); National Institute of Environmental Health Sciences (P30 ES036084); Wayne State University (P30 ES020957)
Based on 4 listed funder(s).
Publication
- Published
- 2024-09-06 · Environ Toxicol Pharmacol · vol. 111 · p. 104562
- Publisher
- Elsevier BV
- Cited
- 5 citations · more than 76% of similar papers · 1.1× the field average
- References
- 113 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Effects and risks of endocrine disrupting chemicals
- Keywords
- Endocrine system, Endocrine disruptor, Phthalate, Aryl hydrocarbon receptor, In vitro, Environmental chemistry, Chemistry, Receptor, Toxicity, Bioassay, Androgen receptor, Biology, Internal medicine, Hormone, Biochemistry, Medicine, Ecology, Transcription factor
- MeSH
- cell line, myocytes, cardiac, animals, humans, rats, receptors, aryl hydrocarbon, endocrine disruptors
4 authors
From US
- Kyle R. SiegelWayne State University
- Brooklynn R MurrayWayne State University
- Jeff Gearhart
- Christopher Dennis Kassotis · correspondingWayne State University
Abstract
Artificial turf, a consumer product growing in usage in the United States, contains diverse chemicals, some of which are endocrine disruptive. Endocrine effects from turf material extracts have been primarily limited to one component, crumb rubber, of these multi-material products. We present in vitro bioactivities from non-weathered and weathered turf sample extracts, including multiple turf components. All weathered samples were collected from real-world turf fields. Non-weathered versus weathered differentially affected the androgen (AR), estrogen (ER), glucocorticoid (GR), and thyroid receptors (TR) in reporter bioassays. While weathered extracts more efficaciously activated peroxisome proliferator activated receptor γ (PPARγ), this did not translate to greater in vitro adipogenic potential. All turf extracts activated the aryl hydrocarbon receptor (AhR). High AhR-efficacy extracts induced modest rat cardiomyoblast toxicity in an AhR-dependent manner. Our data demonstrate potential endocrine and cardiometabolic effects from artificial turf material extracts, warranting further investigation into potential exposures and human health effects.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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