Ultra-processed foods, allergy outcomes and underlying mechanisms in children: An EAACI task force report
Berni Canani R, Carucci L, Coppola S, D'Auria E, O'Mahony L, Roth-Walter F, Vassilopolou E, Agostoni C, Agache I, Akdis C, De Giovanni Di Santa Severina F, Faketea G, Greenhawt M, Hoffman K, Hufnagel K, Meyer R, Milani GP, Nowak-Wegrzyn A, Nwaru B, Padua I, Paparo L, Diego P, Reese I, Roduit C, Smith PK, Santos A, Untersmayr E, Vlieg-Boerstra B, Venter C
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 38 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- European Academy of Allergy and Clinical Immunology
Based on 1 listed funder(s).
Publication
- Published
- 2024-09-01 · Pediatr Allergy Immunol · vol. 35 · issue 9 · p. e14231
- Publisher
- Wiley
- Cited
- 51 citations · more than 100% of similar papers · 19.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 104 works
- Access
- Free to read
- Research areas
- Consumer Attitudes and Food Labeling · Biochemical Analysis and Sensing Techniques · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Allergy, Asthma, Food allergy, Hygiene hypothesis, Environmental health, Immunology, Pediatrics
- MeSH
- humans, asthma, food hypersensitivity, food handling, child, child, preschool, advisory committees, fast foods, rhinitis, allergic, gastrointestinal microbiome, food, processed
29 authors
From IT, IE, AT, GR, RO, CH, US, GB, BE, PL, SE, PT, AU, NL
- Roberto Berni Canani · correspondingCEINGE Biotecnologie Avanzate Franco Salvatore (Italy); University of Naples Federico II
- Laura R. CarucciCEINGE Biotecnologie Avanzate Franco Salvatore (Italy); University of Naples Federico II
- Serena CoppolaCEINGE Biotecnologie Avanzate Franco Salvatore (Italy); University of Naples Federico II
- Enza D’AuriaUniversity of Milan
- Liam O’MahonyUniversity College Cork; APC Microbiome Institute
- Franziska Roth‐WalterUniversity of Vienna; University of Veterinary Medicine Vienna; Medical University of Vienna
Abstract
Background
Consumption of ultra-processed foods [UPFs] may be associated with negative health outcomes. Limited data exist regarding the potential role of UPFs in the occurrence of allergic diseases. The underlying mechanisms underpinning any such associations are also poorly elucidated.
Methods
We performed a systematic review and narrative evidence synthesis of the available literature to assess associations between UPF consumption and pediatric allergy outcomes (n = 26 papers), including data on the association seen with the gut microbiome (n = 16 papers) or immune system (n = 3 papers) structure and function following PRISMA guidelines.
Results
Dietary exposure to fructose, carbonated soft drinks, and sugar intake was associated with an increased risk of asthma, allergic rhinitis, and food allergies in children. Commercial baby food intake was associated with childhood food allergy. Childhood intake of fructose, fruit juices, sugar-sweetened beverages, high carbohydrate UPFs, monosodium glutamate, UPFs, and advanced glycated end-products (AGEs) was associated with the occurrence of allergic diseases. Exposure to UPFs and common ingredients in UPFs seem to be associated with increased occurrence of allergic diseases such as asthma, wheezing, food allergies, atopic dermatitis, and allergic rhinitis, in many, but not all studies.
Conclusion
More preclinical and clinical studies are required to better define the link between UPF consumption and the risk of allergies and asthma. These observational studies ideally require supporting data with clearly defined UPF consumption, validated dietary measures, and mechanistic assessments to definitively link UPFs with the risk of allergies and asthma.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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