Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial
Li C, Li Y, Wang N, Ge Z, Wang J, Ding B, Bi Y, Wang Y, Wang Y, Peng Z, Yang X, Wang C, Hong Z
Redox biology · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Capital Medical University
- University or hospital
- Beijing Friendship Hospital, Capital Medical University
- University or hospital
- Capital Medical University Affiliated Beijing Friendship Hospital
- Grants
- Beijing Friendship Hospital, Capital Medical University (BFHOS20230001); Beijing Friendship Hospital, Capital Medical University (YYZZ202137)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-09-06 · Redox Biol · vol. 76 · p. 103337
- Publisher
- Elsevier BV
- Cited
- 14 citations · more than 93% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Nutrition and Health in Aging · GDF15 and Related Biomarkers · Nutritional Studies and Diet
- Keywords
- Whole grains, Inflammation, Immune system, Consumption (sociology), Context (archaeology), Population, Medicine, Environmental health, Immunology, Biology, Food science
- MeSH
- cd4-positive t-lymphocytes, humans, inflammation, cytokines, diet, dietary fiber, aged, middle aged, female, male, whole grains, interleukin-22
13 authors
From CN
- Cheng LiCapital Medical University; Beijing Friendship Hospital
- Yaru LiCapital Medical University; Beijing Friendship Hospital
- Nan WangCapital Medical University; Beijing Friendship Hospital
- Zhiwen GeCapital Medical University; Beijing Friendship Hospital
- Jia WangCapital Medical University; Beijing Friendship Hospital
- Bingjie DingCapital Medical University; Beijing Friendship Hospital
Abstract
Background and aims
Whole grain consumption is widely recognized as a vital component of a balanced diet. Dietary fiber has been well-documented to play a crucial role in these health benefits attributed to whole grain intake. However, population-based evidence directly linking whole grain consumption to anti-inflammatory effects, especially in the context of immune-mediated inflammation, remains limited. We hypothesized that whole grain consumption promotes health by modulating immune-mediated inflammation.
Methods and results
This study was designed as a real-world, population-based randomized controlled trial. We compared the effects of whole grain versus refined grain consumption on immune-mediated inflammation through staple food substitution, while participants maintained their usual dietary practices. The results demonstrated that whole grain consumption significantly reduced circulating levels of pro-inflammatory cytokines IL-22 and IL-23 compared to refined grain consumption. These reductions were associated with optimized short-chain fatty acid profiles and changes in CD4+ T cell subset distributions.
Conclusions
The findings suggest that the anti-inflammatory effects of whole grain consumption in middle-aged and elderly populations are mediated by targeting specific CD4+ T cell subsets, in addition to modulating both upstream short-chain fatty acid composition and downstream expression of the pro-inflammatory cytokines IL-22 and IL-23.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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