Impact of Magnesium Supplementation on Blood Pressure: An Umbrella Meta-Analysis of Randomized Controlled Trials
Alharran AM, Alzayed MM, Jamilian P, Prabahar K, Kamal AH, Alotaibi MN, Elshaer OE, Alhatm M, Masmoum MD, Hernández-Wolters B, Sindi R, Kord-Varkaneh H, Abu-Zaid A
Current therapeutic research, clinical and experimental · 14 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2024-01-01 · Curr Ther Res Clin Exp · vol. 101 · p. 100755
- Publisher
- Elsevier BV
- Cited
- 14 citations · more than 80% of similar papers · 1.5× the field average
- References
- 45 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Sodium Intake and Health
- Keywords
- Meta-analysis, Randomized controlled trial, Magnesium, Blood pressure, Medicine, Internal medicine, Materials science, Metallurgy
13 authors
From BH, GB, SA, MX, IR
- Abdullah M AlharranArabian Gulf University
- Mooza M AlzayedArabian Gulf University
- Parsa JamilianKeele University
- Kousalya PrabaharUniversity of Tabuk
- Aminah Hassan KamalKing Faisal Specialist Hospital & Research Centre
- Muteb N AlotaibiAlfaisal University
Abstract
Background and aim
Conflicting results on the effect of magnesium supplementation on blood pressure have been published in previous meta-analyses; hence, we conducted this umbrella meta-analysis of RCTs to provide a more robust conclusion on its effects.
Methods
Four databases including PubMed, Scopus, EMBASE, and Web of Science were searched to find pertinent papers published on international scientific from inception up to July 15, 2024. We utilized STATA version 17.0 to carry out all statistical analyses (Stata Corporation, College Station, TX, US). The random effects model was used to calculate the overall effect size ES and CI.
Findings
Ten eligible review papers with 8610 participants studied the influence of magnesium on SBP and DBP. The pooling of their effect sizes resulted in a significant reduction of SBP (ES = -1.25 mmHg; 95% CI: -1.98, -0.51, P = 0.001) and DBP (ES = -1.40 mmHg; 95% CI: -2.04, -0.75, P = 0.000) by magnesium supplementation. In subgroup analysis, a significant reduction in SBP and DBP was observed in magnesium intervention with dosage ≥400 mg/day (ES for SBP = -6.38 mmHg; ES for DBP = -3.71mmHg), as well as in studies with a treatment duration of ≥12 weeks (ES for SBP = -0.42 mmHg; ES for DBP = -0.45 mmHg).
Implications
The findings of the present umbrella meta-analysis showed an overall decrease of SBP and DBP with magnesium supplementation, particularly at doses of ≥400 mg/day for ≥12 weeks.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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