Association of Ultraprocessed Foods Intake with Untargeted Metabolomics Profiles in Adolescents and Young Adults in the DONALD Cohort Study
Muli S, Blumenthal A, Conzen CA, Benz ME, Alexy U, Schmid M, Keski-Rahkonen P, Floegel A, Nöthlings U
The Journal of nutrition · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- World Health Organization
- Government
- Deutsche Forschungsgemeinschaft
- Government
- Agence Nationale de la Recherche
- Government
- Bundesministerium für Bildung und Forschung
- Government
- Federal Ministry of Education and Research Bonn Office
- Government
- German Research Foundation
- Grants
- Deutsche Forschungsgemeinschaft (406710821); Agence Nationale de la Recherche (ANR-18-CE92-0060); Bundesministerium für Bildung und Forschung (01EA1410A)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-09-25 · J Nutr · vol. 154 · issue 11 · pp. 3255–3265
- Publisher
- Elsevier BV
- Cited
- 6 citations · more than 89% of similar papers · 2.3× the field average
- References
- 84 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Food composition and properties
- Keywords
- Metabolomics, Environmental health, Public health, Cohort, Cohort study, Medicine, Gerontology, Biology, Bioinformatics, Internal medicine, Pathology
- MeSH
- humans, diet, cohort studies, longitudinal studies, cross-sectional studies, food handling, adolescent, adult, diet records, female, male, metabolomics, young adult, fast foods, biomarkers
9 authors
From DE, FR
- Samuel MuliUniversity of Bonn
- Annika BlumenthalUniversity of Bonn
- Christina‐Alexandra ConzenUniversity of Bonn
- Maike Elena BenzUniversity of Bonn
- Ute AlexyUniversity of Bonn
- Matthias C. SchmidUniversity Hospital Bonn; Institut für Medizinische Biometrie, Informatik und Epidemiologie
Abstract
Background
High consumption of ultraprocessed foods (UPFs) continues to draw significant public health interest because of the associated negative health outcomes. Metabolomics can contribute to the understanding of the biological mechanisms through which UPFs may influence health.
Objectives
To investigate urine and plasma metabolomic biomarkers of UPF intake in adolescents and young adults.
Methods
We used data from the Dortmund Nutritional and Anthropometric Longitudinally Designed study to investigate cross-sectional associations of UPF intake with concentrations of urine metabolites in adolescents using 3d weighed dietary records (3d-WDR) and 24-h urine samples (n = 339), and associations of repeatedly assessed UPF intake with concentrations of circulating plasma metabolites in young adults with 3-6 3d-WDRs within 5 y preceding blood measurement (n = 195). Urine and plasma samples were analyzed using mass spectrometry-based metabolomics. Biosample-specific metabolite patterns (MPs) were determined using robust sparse principal components analysis. Multivariable linear regression models were applied to assess the associations of UPF consumption (as a percentage of total food intake in g/d) with concentrations of individual metabolites and MP scores.
Results
The median proportion of UPF intake was 22.0% [interquartile range (IQR): 12.3, 32.9] in adolescents and 23.2% (IQR: 16.0, 31.6) in young adults. We identified 42 and 6 UPF intake-associated metabolites in urine and plasma samples, respectively. One urinary MP, "xenobiotics and amino acids" [β = 0.042, 95% confidence interval (CI): 0.014, 0.070] and 1 plasma MP, "lipids, xenobiotics, and amino acids" (β = 0.074, 95% CI: 0.031, 0.117) showed positive association with UPF intake. Both patterns shared 29 metabolites, mostly of xenobiotic metabolism.
Conclusions
We identified urine and plasma metabolites associated with UPF intake in adolescents and young adults, which may represent some of the biological mechanisms through which UPFs may influence metabolism and health.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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