Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial
Manoogian ENC, Wilkinson MJ, O'Neal M, Laing K, Nguyen J, Van D, Rosander A, Pazargadi A, Gutierrez NR, Fleischer JG, Golshan S, Panda S, Taub PR
Annals of internal medicine · 43 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Larry L. Hillblom Foundation
- Government
- National Institutes of Health
- University or hospital
- University of California, San Diego
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Grants
- National Center for Advancing Translational Sciences (NIH KL2TR001444); National Center for Advancing Translational Sciences (UL1TR001442.); National Center for Advancing Translational Sciences (KL 2TR001444); University of California, San Diego (KL2TR001444); National Cancer Institute (P30 CA-014195); University of California, San Diego (UL1TR001442); National Cancer Institute (R01 CA258221); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK118278); National Institutes of Health (DK118278); National Institutes of Health (KL2TR001444); National Institutes of Health (UL1 TR001442.); National Institutes of Health (P30 CA014195)
Based on 9 listed funder(s).
Publication
- Published
- 2024-09-30 · Ann Intern Med · vol. 177 · issue 11 · pp. 1462–1470
- Publisher
- American College of Physicians
- Cited
- 62 citations · more than 99% of similar papers · 14.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 27 works
- Access
- Open access (repository copy)
- Research areas
- Dietary Effects on Health · Enhanced Recovery After Surgery · Circadian rhythm and melatonin
- Keywords
- Medicine, Metabolic syndrome, Obesity, Internal medicine, Gerontology, Physiology
- MeSH
- humans, insulin resistance, insulin, blood glucose, caloric restriction, fasting, counseling, time factors, adult, middle aged, female, male, metabolic syndrome, glycated hemoglobin
13 authors
From US
- Emily N. C. ManoogianSalk Institute for Biological Studies
- Michael J. WilkinsonUniversity of California San Diego
- Monica A. O'NealSalk Institute for Biological Studies
- Kyla L. LaingSalk Institute for Biological Studies
- Justina NguyenUniversity of California San Diego
- David T. VanUniversity of California San Diego
Abstract
Background
Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.
Objective
To determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.
Design
Randomized controlled trial. (ClinicalTrials.gov: NCT04057339).
Setting
Clinical research institute.
Participants
Adults with metabolic syndrome including elevated fasting glucose or hemoglobin A1c (HbA1c; pharmacotherapy allowed).
Intervention
Participants were randomly assigned to standard-of-care (SOC) nutritional counseling alone (SOC group) or combined with a personalized 8- to 10-hour TRE intervention (≥4-hour reduction in eating window) (TRE group) for 3 months. Timing of dietary intake was tracked in real time using the myCircadianClock smartphone application.
Measurements
Primary outcomes were HbA1c, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and glycemic assessments from continuous glucose monitors.
Results
108 participants from the TIMET study completed the intervention (89% of those randomly assigned; 56 women, mean baseline age, 59 years; body mass index of 31.22 kg/m2; eating window of 14.19 hours). Compared with SOC, TRE improved HbA1c by -0.10% (95% CI, -0.19% to -0.003%). Statistical outcomes were adjusted for age. There were no major adverse events.
Limitation
Short duration, self-reported diet, potential for multiple elements affecting outcomes.
Conclusion
Personalized 8- to 10-hour TRE is an effective practical lifestyle intervention that modestly improves glycemic regulation and may have broader benefits for cardiometabolic health in adults with metabolic syndrome on top of SOC pharmacotherapy and nutritional counseling.
Primary funding source
National Institutes of Health.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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