Cold Exposure Therapy Sensitizes Nanodrug-Mediated Radioimmunotherapy of Breast Cancer
Qiao K, Pan Y, Zhang S, Shi G, Yang J, Zhang Z, Wang K, Chen X, Ning S
ACS nano · 21 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- Government
- Ministry of Health -Singapore
- University or hospital
- National University of Singapore
- Government
- National Research Foundation Singapore
- Government
- Ministry of Education - Singapore
- Government
- National Natural Science Foundation of China
- Government
- National Medical Research Council
- Grants
- National Medical Research Council ((MOH-001388-00); Ministry of Education - Singapore (MOE- 000387-00); National Research Foundation Singapore (NRF‐000352‐00); National University of Singapore (NUHSRO/2023/008/NUSMed/TCE/LOA); National Natural Science Foundation of China (82303500); National Medical Research Council (MOH‐001041); National University of Singapore (NUHSRO/2021/0 34/TRP/09/Nanomedicine); National Natural Science Foundation of China (82473348); Natural Science Foundation of Guangxi Zhuang Autonomous Region (2023GXNSFBA026137); National University of Singapore (NUHSRO/ 2020/133/Startup/08); Ministry of Health -Singapore (MOH- 001388-00); Ministry of Health -Singapore (CG21APR1005); Ministry of Health -Singapore (MOH-001041); National Medical Research Council (CG21APR1005); National Natural Science Foundation of China (82303797)
Based on 7 listed funder(s).
Publication
- Published
- 2024-10-14 · ACS Nano · vol. 18 · issue 43 · pp. 29689–29703
- Publisher
- American Chemical Society
- Cited
- 30 citations · more than 94% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 65 works
- Access
- Paywalled
- Research areas
- Nanoplatforms for cancer theranostics · Cancer, Stress, Anesthesia, and Immune Response · Immune cells in cancer
- Keywords
- Cancer research, Peroxynitrite, Tumor microenvironment, Nitric oxide, Chemistry, Glutathione, Pharmacology, Superoxide, Medicine, Internal medicine, Biochemistry, Tumor cells
- MeSH
- cell line, tumor, animals, mice, inbred balb c, humans, mice, breast neoplasms, nitric oxide, antineoplastic agents, liposomes, radioimmunotherapy, cryotherapy, cell proliferation, female, nanoparticles, cold temperature
9 authors
From CN, SG, FR
- Kun QiaoHarbin Medical University; Third Affiliated Hospital of Harbin Medical University
- Pan YouGuangxi Medical University
- Shiyuan ZhangHarbin Medical University; Third Affiliated Hospital of Harbin Medical University
- Guangfu ShiGuangxi Medical University
- Jinglin YangGuangxi Medical University
- Zhenlin ZhangGuangxi Medical University
Abstract
Cold exposure (CE) therapy can quickly induce tumor starvation by brown adipose tissue (BAT) thermogenesis. Exploring the combined antitumor mechanism of CE and traditional therapies (such as radiotherapy (RT)) is exciting and promising. In this study, we investigated the effect of CE in combination with nitric oxide (NO) gas therapy on sensitizing tumors to RT and promoting tumor radio-immunotherapy. We first constructed a liposome (SL) loaded with the NO prodrug S-nitroso-N-acetylpenicillamine (SNAP). When SL is injected, the glutathione (GSH) within the tumor region promotes the release of NO from SNAP. Subsequently, the superoxide anion produced by RT reacts with NO to generate peroxynitrite (ONOO-), which has strong oxidative properties and induces cell death. Meanwhile, the mice were exposed to a CE environment of 4 °C. CE-mediated BAT thermogenesis induced tumor starvation, which led to a decrease in ATP and GSH content within the tumor as well as an improvement in the hypoxic microenvironment and a decrease in myeloid-derived suppressor cells. All of the above have promoted the effectiveness of RT and activated the systemic antitumor immunity. In the bilateral tumor experiment, treatment of the primary tumor inhibited the growth of the distant tumor and promoted the infiltration of CD8+ T cells into the tumor. These findings reveal that the synergy of CE, NO gas therapy, and RT could confer high effective anticancer effects, providing possibilities in personalized cancer treatment.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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