Comparing the effects of time-restricted eating on glycaemic control in people with type 2 diabetes with standard dietetic practice: A randomised controlled trial
Parr EB, Radford BE, Hall RC, Steventon-Lorenzen N, Flint SA, Siviour Z, Plessas C, Halson SL, Brennan L, Kouw IWK, Johnston RD, Devlin BL, Hawley JA
Diabetes research and clinical practice · 24 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Diabetes Australia
- University or hospital
- Australian Catholic University
- Grants
- Diabetes Australia (20YG-PARE)
Based on 2 listed funder(s).
Publication
- Published
- 2024-10-15 · Diabetes Res Clin Pract · vol. 217 · p. 111893
- Publisher
- Elsevier BV
- Cited
- 36 citations · more than 98% of similar papers · 8.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 44 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Dietary Effects on Health · Enhanced Recovery After Surgery · Nutritional Studies and Diet
- Keywords
- Medicine, Type 2 diabetes, Diabetes mellitus, Control (management), Gerontology, Physical therapy, Endocrinology, Artificial intelligence
- MeSH
- humans, diabetes mellitus, type 2, obesity, blood glucose, dietetics, adult, aged, middle aged, female, male, glycemic control, glycated hemoglobin, intermittent fasting
13 authors
From AU, NL, GB
- Evelyn B. Parr · correspondingAustralian Catholic University
- Bridget E. RadfordAustralian Catholic University
- Rebecca C. HallAustralian Catholic University
- Nikolai Steventon-LorenzenAustralian Catholic University
- Steve A. FlintAustralian Catholic University
- Zoe SiviourAustralian Catholic University
Abstract
Aims
To test the efficacy of time-restricted eating (TRE) in comparison to dietitian-led individualised dietary guidance to improve HbA1c in people with Type 2 diabetes mellitus.
Methods
In a parallel groups design, 51 adults (35-65 y) with Type 2 diabetes mellitus and overweight/obesity (HbA1c ≥6.5% (48 mmol/mol), BMI ≥25-≤40 kg/m2) commenced a six-month intervention. Following baseline, participants were randomised to TRE (1000-1900 h) or DIET (individualised dietetic guidance) with four consultations over four months. Changes in HbA1c (primary), body composition, and self-reported adherence (secondary) were analysed using linear mixed models. A non-inferiority margin of 0.3% (4 mmol/mol) HbA1c was set a priori.
Results
Forty-three participants (56 ± 8 y, BMI: 33 ± 5 kg/m2, HbA1c: 7.6 ± 0.8%) completed the intervention. HbA1c was reduced (P=0.002; TRE: -0.4% (-5 mmol/mol), DIET: -0.3% (-4 mmol/mol)) with no group or interaction effects; TRE was non-inferior to DIET (-0.11%, 95%CI: -0.50% to 0.28%). Body mass reduced in both groups (TRE: -1.7 kg; DIET: -1.2 kg) via ∼900 kJ/d spontaneous energy reduction (P<0.001). Self-reported adherence was higher in TRE versus DIET (P<0.001).
Conclusions
When individualised dietary guidance is not available, effective, and/or suitable, TRE may be an alternative dietary strategy to improve glycaemic control in people with Type 2 diabetes mellitus.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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