The Effect of Repeated Low-Level Red-Light Therapy on Myopia Control and Choroid
Liu Y, Zhu M, Yan X, Li M, Xiang Y
Translational vision science & technology · 17 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (82000893); National Natural Science Foundation of China (81800821)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-10-21 · Transl Vis Sci Technol · vol. 13 · issue 10 · p. 29
- Publisher
- Association for Research in Vision and Ophthalmology
- Cited
- 20 citations · more than 96% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Laser Applications in Dentistry and Medicine · Corneal surgery and disorders · Retinal Diseases and Treatments
- Keywords
- Choroid, Ophthalmology, Medicine, Light therapy, Optometry, Retina, Neuroscience, Biology, Internal medicine
- MeSH
- choroid, humans, myopia, tomography, optical coherence, refraction, ocular, treatment outcome, follow-up studies, adult, female, male, young adult, axial length, eye, low-level light therapy
5 authors
From CN
- Ying LiuTongji Hospital; Huazhong University of Science and Technology
- Mengxia ZhuTongji Hospital; Huazhong University of Science and Technology
- Xiaoqin YanTongji Hospital; Huazhong University of Science and Technology
- Mu Li · correspondingWuhan Union Hospital; Huazhong University of Science and Technology
- Yan XiangTongji Hospital; Huazhong University of Science and Technology
Abstract
Purpose
To investigate the long-term effects of repeated low-level red light (RLRL) therapy on the axial length (AL), spherical equivalent (SE), and choroidal parameters.
Methods
Two hundred eight myopic eyes were recruited. The RLRL group included 100 eyes, whereas the control group included 108 eyes. Throughout the one-year follow-up period, changes in AL and SE were recorded for both groups. The RLRL group underwent additional choroidal imaging, and changes in choroidal thickness (CT), choroidal vascularity (CV), and choriocapillaris luminal area (CLA) were assessed before and after RLRL therapy.
Results
During the follow-up period, the changing trends in AL and SE differed significantly between the RLRL and control groups. In the RLRL group, AL decreased at three and six months (both P < 0.05) and returned to pretreatment values at 12 months (P = 0.453). In contrast, AL increased significantly throughout the follow-up period (three, six, and 12 months) in the control group (all P < 0.001). The SE increased significantly during the entire follow-up period in the RLRL group (all P < 0.001), whereas it decreased significantly in the control group (all P < 0.05). Regarding choroidal parameters, significant improvements were observed in CT, CV and CLA throughout the follow-up period (all P < 0.05), and changes in most choroidal parameters were significantly correlated with changes in AL and SE during the follow-up period (all P < 0.05). Furthermore, AL, SE, and most choroidal parameters showed significant correlations between changes at three and 12 months (all P < 0.05).
Conclusions
RLRL therapy significantly improved choroidal blood perfusion and circulation, which may explain the observed slowing or reversal of myopia progression in the RLRL group. Thus RLRL therapy may be a novel and effective method for controlling myopia. Furthermore, the short-term effect of photobiomodulation therapy (i.e., changes at three months) can be used to predict the long-term effects (i.e., changes at 12 months).
Translational relevance
In this study, RLRL therapy showed a significant control effect on the development of axial length and spherical equivalent. RLRL therapy also promoted the choroidal blood perfusion and circulation. RLRL therapy could be a novel and effective method for myopia control.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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