Effects of healthy low-carbohydrate diet and time-restricted eating on weight and gut microbiome in adults with overweight or obesity: Feeding RCT
Li L, Li R, Tian Q, Luo Y, Li R, Lin X, Ou Y, Guo T, Chen X, Pan A, Manson JE, Liu G
Cell reports. Medicine · 27 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Deutsches Krebsforschungszentrum
- Government
- National Natural Science Foundation of China
- University or hospital
- Huazhong University of Science and Technology
- University or hospital
- Tongji University
- Government
- Fundamental Research Funds for the Central Universities
- University or hospital
- Tongji Medical College, Huazhong University of Science and Technology
- Grants
- National Natural Science Foundation of China (82325043); Fundamental Research Funds for the Central Universities (2021GCRC076); National Natural Science Foundation of China (82073554)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-10-24 · Cell Rep Med · vol. 5 · issue 11 · p. 101801
- Publisher
- Elsevier BV
- Cited
- 35 citations · more than 98% of similar papers · 7.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 80 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Gut microbiota and health
- Keywords
- Overweight, Weight loss, Obesity, Body mass index, Microbiome, Randomized controlled trial, Feces, Medicine, Gut flora, Internal medicine, Food science, Physiology, Endocrinology, Biology, Bioinformatics, Immunology, Ecology
- MeSH
- feces, humans, obesity, body weight, weight loss, body mass index, caloric restriction, adult, middle aged, female, male, overweight, diet, carbohydrate-restricted, gastrointestinal microbiome
12 authors
From CN, US
- Lin LiHuazhong University of Science and Technology
- Rui LiHuazhong University of Science and Technology
- Qingying TianHuazhong University of Science and Technology
- Yaogan LuoShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Ruyi LiHuazhong University of Science and Technology
- Xiaoyu LinHuazhong University of Science and Technology
Abstract
The effect of a healthy low-carbohydrate diet (HLCD) and time-restricted eating (TRE), alone or in combination, on body weight and gut microbiome beyond caloric restriction remains unclear. In this 12-week two-by-two factorial randomized trial with a 28-week follow-up among 96 participants with overweight or obesity, isocaloric-restricted feeding yields significant weight loss, ranging from 2.57 to 4.11 kg across different groups. Beyond caloric restriction, HLCD and TRE lead to additional reduction in body mass index. HLCD results in additional fat mass loss while TRE yields more lean mass loss. Additionally, HLCD leads to decreased fecal branched-chain amino acids, and TRE tends to yield an increased abundance of probiotic species involved in synthesizing short-chain fatty acids. Moreover, the effect of HLCD on reducing fat mass is sustained during the post-intervention follow-up. Overall, HLCD and TRE are effective in weight management and yield profound gut microbiome and metabolome alteration beyond caloric restriction. This study was registered at ChiCTR.org.cn (ChiCTR2200056363).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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