Association Between Ultraprocessed Food Consumption and Metabolic Disorders in Children and Adolescents with Obesity
Lee GY, Lim JH, Joung H, Yoon D
Nutrients · 20 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Institute of Health (NIH)
- Government
- National Institute of Health
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-10-17 · Nutrients · vol. 16 · issue 20 · p. 3524
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 23 citations · more than 98% of similar papers · 8.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 97 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Food composition and properties
- Keywords
- Medicine, Insulin resistance, Obesity, Odds ratio, Body mass index, Confidence interval, Internal medicine, Metabolic syndrome, Endocrinology
- MeSH
- humans, fatty liver, metabolic diseases, insulin resistance, diet, food handling, adolescent, child, diet records, female, male, adiposity, fast foods, pediatric obesity
4 authors
From KR
- Gyeong-yoon LeeSeoul National University; Korea National Institute of Health
- Joo Hyun LimKorea National Institute of Health
- Hyojee Joung · correspondingSeoul National University
- Dankyu Yoon · correspondingKorea National Institute of Health
Abstract
Background/objectives
We investigated the effects of ultraprocessed food (UPF) consumption on metabolic disorders (e.g., adiposity, metabolic associated steatotic liver disease [MASLD], and insulin resistance) in children and adolescents with obesity to improve dietary guidelines and public health strategies.
Methods
The dietary intake of 149 participants (aged 8-17 years) was assessed with food diaries. The NOVA classification system was used to classify food according to the degree of processing. Metabolic outcomes, including the fat mass index (FMI), hepatic fat percentage, and insulin resistance, were measured via dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging proton density fat fraction (MRI-PDFF), and biochemical analysis, respectively.
Results
Greater UPF consumption from baseline to the 6-month follow-up was significantly associated with increased insulin and decreased total cholesterol and LDL-cholesterol. UPF consumption was positively associated with the prevalence of MASLD (liver MRI-PDFF ≥ 5%; odds ratio T3 vs. T1 = 1.75; 95% confidence interval [CI] 1.03, 3.00), moderate-to-severe MASLD (liver MRI-PDFF ≥ 10%; OR T3 vs. T1 = 4.19; 95% CI 1.72, 10.22), and insulin resistance (OR T3 vs. T1 = 2.44; 95% CI 1.33, 4.48), after adjusting for covariates. A linear dose-response relationship was observed between UPF consumption and the odds of moderate-to-severe MASLD and insulin resistance.
Conclusions
Greater UPF consumption was strongly associated with MASLD and insulin resistance in children and adolescents with obesity, underscoring the importance of reducing UPF consumption through dietary guidelines and public health interventions to mitigate the risk of obesity-related metabolic conditions in young populations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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