Funded in part by Ixoreal BioMed Inc
Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
Kale S, Lopresti A, Suri R, Garg N, Langade D
Journal of psychoactive drugs · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Ixoreal BioMed Inc
Based on 1 listed funder(s).
Publication
- Published
- 2024-11-05 · J Psychoactive Drugs · vol. 58 · issue 1 · pp. 45–57
- Publisher
- Taylor & Francis
- Cited
- 9 citations · more than 94% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Phytochemicals and Medicinal Plants · Complementary and Alternative Medicine Studies · Medicinal Plants and Neuroprotection
- Keywords
- Mood, Cognition, Placebo, Randomized controlled trial, Medicine, Root (linguistics), Clinical psychology, Psychology, Psychiatry, Physical therapy, Alternative medicine, Internal medicine
- MeSH
- humans, plant roots, plant extracts, treatment outcome, phytotherapy, prospective studies, double-blind method, mental fatigue, affect, cognition, cognition disorders, mood disorders, adult, aged, middle aged, female, male, executive function
5 authors
From IN, US
- Sanjiv S. KaleD.Y. Patil University
- Adrian L. LoprestiClinical Research Management
- Ravleen K Suri · correspondingD.Y. Patil University
- Neha GargD.Y. Patil University
- Deepak LangadeD.Y. Patil University
Abstract
This prospective, randomized, placebo-controlled study assessed the effects of Ashwagandha root extract (ARE) on cognition, energy, and mood in adults with self-reported cognitive and energy problems. Healthy subjects aged 30-75 years were randomized to receive ashwagandha (Withania somnifera) root extract (ARE) 600 mg/day (n = 60)/identical placebo (n = 60) orally for 8 weeks. Cognitive function was assessed at baseline and week 8 using a Computerized Mental Performance Assessment System (COMPASS). Secondary outcomes were Profile of Mood States Abbreviated Version (POMS-A), Mental Fatigue Scale (MFS) and Behavior Rating Inventory of Executive Function-Adult (BRIEF-A) for effects on mood, mental fatigue and executive function, respectively, assessed at baseline, week 4 and 8. Greater improvement (p < .05) from baseline scores were seen with ARE as against placebo for COMPASS items episodic memory, working memory and accuracy of attention. ARE also improved the POMS-A, MFS and BRIEF-A scores from baseline suggesting an improvement in mood, vigor, and an increase in the executive functioning respectively with ARE. The herb was well tolerated and had a good patient compliance with no serious adverse events reported in either of the groups. This study suggests that a dose of 600 mg a day can improve cognition, energy, and mood in adults with self-reported cognitive and energy problems.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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