Safety of and chorioretinal circulation during repeated low-level red-light therapy for myopic children
Jiang Z, Chen S, Wang R, Ma J
Clinical & experimental ophthalmology · 8 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Natural Science Foundation of Guangdong Province
- Government
- National Key Research and Development Program of China
- Government
- Guangdong Natural Science Foundation
- Grants
- National Key Research and Development Program of China (2023YFC2506100); Natural Science Foundation of Guangdong Province (2023A1515012470)
Based on 3 listed funder(s).
Publication
- Published
- 2024-11-05 · Clin Exp Ophthalmol · vol. 53 · issue 2 · pp. 119–132
- Publisher
- Wiley
- Cited
- 11 citations · more than 95% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 26 works
- Access
- Free to read
- Research areas
- Retinal Diseases and Treatments · Laser Applications in Dentistry and Medicine · Retinopathy of Prematurity Studies
- Keywords
- Medicine, Microperimetry, Ophthalmology, Retinal, Refractive error, Emmetropia, Fundus (uterus), Visual acuity
- MeSH
- microcirculation, retinal vessels, choroid, humans, myopia, tomography, optical coherence, fluorescein angiography, electroretinography, phototherapy, single-blind method, eyeglasses, regional blood flow, visual acuity, adolescent, child, female, male, axial length, eye
4 authors
From CN
- Zhaoxin JiangSun Yat-sen University
- Shuyu ChenSun Yat-sen University
- Renchun WangSun Yat-sen University
- Jin Ma · correspondingSun Yat-sen University
Abstract
Background
To evaluate the safety of repeated low-level red-light (RLRL) therapy in children, and the dynamic evolution of choroidal and retinal blood flow.
Methods
This is a single-centre, randomised, single-blind, parallel-group clinical trial. Seventy myopic children were randomly assigned to either the intervention group [receiving RLRL therapy plus single-vision spectacle (SVS)] or the control group (wearing SVS). Participants underwent comprehensive ophthalmic examinations following their first irradiation, 9 months continuous RLRL therapy and stop of treatment. Quantitative analyses of choroidal and retinal microcirculation were analysed via optical coherence tomography angiography.
Results
Over 9 months of treatment, while the RLRL treatment demonstrated significantly less increases in refractive error and axial length compared with the SVS treatment (ps 0.05). A single red-light exposure did not exert a significant influence on choroidal thickness (ps > 0.05). Upon continuous treatment, the RLRL group achieved peak values in these circulations at 9 months (ps 0.05). As the frequency of red-light exposures intensified, there was a consistent surge in these circulations (ps < 0.05).
Conclusions
Nine months of continuous RLRL exposure does not cause toxic side effects on retinal or optic nerve functions, and there is a time-dependent cumulative response in choroidal and retinal circulation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.