Effect of the Mediterranean Diet Supplemented With Olive Oil Versus the Low-Fat Diet on Serum Inflammatory and Endothelial Indexes Among Adults: A Systematic Review and Meta-analysis of Clinical Controlled Trials
Pourrajab B, Fotros D, Asghari P, Shidfar F
Nutrition reviews · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2024-10-10 · Nutr Rev · vol. 83 · issue 7 · pp. e1421–e1440
- Publisher
- Oxford University Press
- Cited
- 15 citations · more than 86% of similar papers · 1.9× the field average
- References
- 88 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Edible Oils Quality and Analysis · Fatty Acid Research and Health
- Keywords
- Mediterranean diet, Meta-analysis, Medicine, Olive oil, Context (archaeology), Internal medicine, MEDLINE, Clinical trial, Randomized controlled trial, Systematic review, Endothelial dysfunction, Inflammation, Gerontology, Physiology, Food science, Biology
- MeSH
- endothelium, vascular, humans, inflammation, diet, fat-restricted, diet, mediterranean, dietary supplements, adult, middle aged, female, male, controlled clinical trials as topic, olive oil
4 authors
From IR
- Behnaz PourrajabNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Danial FotrosNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Parastoo AsghariMashhad University of Medical Sciences
- Farzad Shidfar · correspondingIran University of Medical Sciences
Abstract
Context
Inflammation and endothelial dysfunction are important risk factors for chronic diseases, including cardiovascular diseases and related mortality.
Objective
This systematic review and meta-analysis aimed to assess the effects of 2 popular dietary patterns-a Mediterranean (MED) diet supplemented with olive oil and a low-fat diet (LFD)-on factors related to inflammation and endothelial function in adults.
Data sources and data extraction
The following online databases were searched for related studies published until August 7, 2024: PubMed/Medline, Scopus, Clarivate Analytics Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar. Two independent researchers selected the studies based on the eligibility criteria.
Data analysis
The effect sizes were expressed as Hedges' g with 95% CIs. A total of 16 eligible trials with 20 effect sizes were included in the analyses. This meta-analysis revealed that the MED diet supplemented with olive oil significantly improved all of the indicators of the study compared with the LFD, except in the case of E-selectin, in which a low and nonsignificant decrease was reported.
Conclusion
Available evidence suggests that a MED diet supplemented with olive oil compared with the LFD significantly improves inflammation and serum endothelial function in adults.
Systematic review registration
PROSPERO registration no. CRD42023485718.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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