Bone and vascular effects of magnesium supplements in CKD patients (the MagicalBone Pilot Study)
Pendón-Ruiz de Mier MV, Santamaría R, Moyano-Peregrín C, Gordillo JE, Salmoral-Chamizo A, López-López I, Rodelo-Haad C, Valle C, Membrives-González C, López-Ruiz DJ, Álvarez-Benito M, López-Baltanás R, Torralbo AI, Valdés-Díaz KC, García-Sáez RM, Jurado-Montoya D, Pinaglia-Tobaruela G, Martínez-Moreno JM, Martín-Malo A, Soriano S, Rodríguez M, Rodríguez-Ortiz ME, Muñoz-Castañeda JR
Nefrologia · 5 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Sociedad Española de Nefrología
- Government
- Consejería de Transformación Económica, Industria, Conocimiento y Universidades
- Nonprofit
- Federación Española de Enfermedades Raras
- Government
- Consejería de Salud y Familias, Junta de Andalucía
- Grants
- Consejería de Transformación Económica, Industria, Conocimiento y Universidades (PY20_00773); Consejería de Transformación Económica, Industria, Conocimiento y Universidades (RICORS2040); Consejería de Salud y Familias, Junta de Andalucía (PI-0154-2017); Consejería de Salud y Familias, Junta de Andalucía (PI-0071-2021)
Based on 4 listed funder(s).
Publication
- Published
- 2024-09-01 · Nefrologia (Engl Ed) · vol. 44 · issue 5 · pp. 721–730
- Publisher
- Elsevier BV
- Cited
- 6 citations · more than 78% of similar papers · 1.3× the field average
- References
- 39 works
- Access
- Open access (free to publish) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Bone health and osteoporosis research
- Keywords
- Magnesium, Medicine, Internal medicine, Metallurgy, Materials science
- MeSH
- humans, magnesium, pilot projects, bone density, dietary supplements, aged, middle aged, female, male, renal insufficiency, chronic, vascular calcification, pulse wave analysis
23 authors
From ES
- M. Victoria Pendón-Ruiz de MierInstituto Maimónides de Investigación Biomédica de Córdoba
- Rafael SantamaríaInstituto Maimónides de Investigación Biomédica de Córdoba
- Cayetana Moyano-PeregrínInstituto Maimónides de Investigación Biomédica de Córdoba; Institute for Research in Biomedicine; University of Córdoba
- José Enrique GordilloHospital Universitario Reina Sofía
- Asunción Salmoral-ChamizoHospital Universitario Reina Sofía
- Isabel López-LópezInstituto Maimónides de Investigación Biomédica de Córdoba; Institute for Research in Biomedicine; University of Córdoba
Abstract
Background and objective
The progression of chronic kidney disease (CKD) involves the development of alterations in mineral metabolism that are closely related to cardiovascular outcomes and bone disease. Hypomagnesemia is associated with more rapid progression of CKD and other comorbidities. Our objective was to analyze in CKD patients stages 3-4 the impact of the administration of magnesium (Mg) carbonate on bone mineral density (BMD) and hemodynamic changes associated with by vascular calcification (VC).
Material and methods
Patients with CKD stages 3-4 were randomized into controls (n=12) or intervention (n=7) group receiving 360mg of Mg carbonate daily during a 15-month period. Parameters related to mineral metabolism, BMD, VC, and pulse wave velocity (PWV) were evaluated.
Results
Supplementation with Mg produced an increase in the urinary excretion of Mg while serum Mg levels remained stable and no episodes of hypermagnesemia were reported. In addition, no significant changes were found in the degree of VC assessed by Adragao index, however, both serum and urine Mg were significantly associated with a decrease in PWV, suggesting an increase in vascular compliance. Likewise, BMD did not change following treatment, but serum Mg significantly correlated with the levels of N-terminal propeptide of collagen alpha-1(I) chain (PINP), a marker of bone synthesis.
Conclusions
In sum, these results suggest a possible beneficial effect of Mg on vascular compliance with no detrimental effects on bone status. In addition, our results highlight the need to consider monitorization of urinary Mg status in CKD patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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