Ashwagandha-Induced Hepatic Injury: A Case Report
Almuzghi F, Abdelmalik A, Abuhlaiga M
Cureus · 7 citations
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2024-10-15 · Cureus · vol. 16 · issue 10 · p. e71576
- Publisher
- Cureus, Inc.
- Cited
- 7 citations · more than 92% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 3 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Complementary and Alternative Medicine Studies · Drug-Induced Hepatotoxicity and Protection · Phytochemicals and Medicinal Plants
- Keywords
- Medicine, Medical emergency
3 authors
From LY, QA
- Fakhruddin AlmuzghiMisurata University; Hamad Medical Corporation
- Abubaker AbdelmalikMisurata University
- Maaly Abuhlaiga
Abstract
A 22-year-old healthy Libyan female suffered moderate to severe liver injury following the ingestion of ashwagandha capsules. Following a latency period of 30 hours, she developed severe itching, fatigue, nausea, and jaundice. Laboratory results showed significantly increased liver enzymes (especially alanine aminotransferase (ALT)) and bilirubin (mainly conjugated bilirubin), along with a slight elevation of alkaline phosphatase (ALP). We used the Roussel Uclaf Causality Assessment Method (RUCAM) worksheet to link liver injury to ashwagandha. The R ratio was 5.4, and the overall RUCAM score was seven. The peaks of ALT, total bilirubin, and ALP were 315 IU/L, 12.85 mg/dl, and 150 IU/L, respectively. The washout period was 60 days. Symptoms were relieved by ursodeoxycholic acid (UDSA). The clinical assessment and workup for viral hepatitis and autoimmune hepatitis were negative. In conclusion, ashwagandha can cause prolonged hepatocellular liver injury in healthy and young individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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