Time-restricted eating reveals a "younger" immune system and reshapes the intestinal microbiome in human
Chen Y, Li X, Yang M, Jia C, He Z, Zhou S, Ruan P, Wang Y, Tang C, Pan W, Long H, Zhao M, Lu L, Peng W, Akbar A, Wu IX, Li S, Wu H, Lu Q
Redox biology · 29 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Science and Technology of the People's Republic of China
- University or hospital
- Chinese Academy of Meteorological Sciences
- Government
- Natural Science Foundation of Hunan Province
- University or hospital
- Chinese Academy of Medical Sciences
- Government
- National Key Research and Development Program of China
- University or hospital
- Chinese Academy of Medical Sciences & Peking Union Medical College
- Government
- Natural Science Foundation of Hunan Province
- Government
- Ministry of Science and Technology of the People's Republic of China
- Grants
- National Natural Science Foundation of China (82273540); National Natural Science Foundation of China (82373488); National Natural Science Foundation of China (32141004); National Key Research and Development Program of China (2022YFC3601800); Natural Science Foundation of Hunan Province (2024JJ4077); Chinese Academy of Medical Sciences (2021-I2M-1-059); Chinese Academy of Medical Sciences (2021-RC320-001); National Natural Science Foundation of China (82173425); National Natural Science Foundation of China (82473530)
Based on 9 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-11-09 · Redox Biol · vol. 78 · p. 103422
- Publisher
- Elsevier BV
- Cited
- 32 citations · more than 98% of similar papers · 7.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 83 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Immunosenescence, Immune system, Microbiome, Calorie, Gut microbiome, Biology, Physiology, Immunology, Medicine, Gerontology, Bioinformatics, Endocrinology
- MeSH
- cd4-positive t-lymphocytes, immune system, humans, adult, middle aged, female, male, gastrointestinal microbiome
19 authors
From CN, FR, HK, GB
- Yiran ChenChinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Medical Sciences Dermatology Hospital
- Xi LiCentral South University; Second Xiangya Hospital of Central South University
- Ming YangCentral South University; Second Xiangya Hospital of Central South University
- Jia ChenCentral South University; Second Xiangya Hospital of Central South University
- Zhenghao HeCentral South University; Second Xiangya Hospital of Central South University
- Suqing ZhouCentral South University; Second Xiangya Hospital of Central South University
Abstract
Time-restricted eating (TRE) has been shown to extent lifespans in drosophila and mouse models by affecting metabolic and anti-inflammatory activities. However, the effect of TRE on the human immune system, especially on immunosenescence, intestinal microbiome, and metabolism remains unclear. We conducted a 30-day 16:8 TRE single-arm clinical trial with 49 participants. Participants consumed daily meals from 9 a.m. to 5 p.m., provided by a nutrition canteen with a balanced, calorie-appropriate nutrition, which is designed by clinical nutritionists (ChiCTR2200058137). We monitored weight changes and weight-related parameters and focused on changes in the frequency of CD4+ senescent T cells, immune repertoire from peripheral blood, as well as serum metabolites and gut microbiota. We found that up to 95.9 % of subjects experienced sustained weight loss after TRE. The frequency of circulating senescent CD4+ T cells was decreased, while the frequency of Th1, Treg, Tfh-like, and B cells was increased. Regarding the immune repertoire, the proportions of T cell receptor alpha and beta chains were increased, whereas B cell receptor kappa and lambda chains were reduced. In addition, a reduced class switch recombination from immunoglobulin M (IgM) to immunoglobulin A (IgA) was observed. TRE upregulated the levels of anti-inflammatory and anti-aging serum metabolites named sphingosine-1-phosphate and prostaglandin-1. Additionally, several anti-inflammatory bacteria and probiotics were increased, such as Akkermansia and Rikenellaceae, and the composition of the gut microbiota tended to be "younger". Overall, TRE showed multiple anti-aging effects, which may help humans maintain a healthy lifestyle to stay "young". Clinical Trial Registration URL: https://www.chictr.org.cn/showproj.html?proj=159876.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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