Association of magnesium intake with predicted atherosclerotic lesions and cardiovascular risk in young adults based on PDAY score: a cross-sectional study
Song Q, Song L, Liu H, Tan H, Yang B, Fan C, Liu L
BMC public health · 2 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Natural Science Foundation of Hainan Province
- Government
- the Natural Science Foundation of Hunan Province
- Grants
- Natural Science Foundation of Hainan Province (LL:2021JC0003)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-11-20 · BMC Public Health · vol. 24 · issue 1 · p. 3232
- Publisher
- BioMed Central
- Cited
- 3 citations · more than 66% of similar papers · 0.6× the field average
- References
- 43 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Medicine, National Health and Nutrition Examination Survey, Dyslipidemia, Cross-sectional study, Odds ratio, Internal medicine, Population, Confounding, Cohort, Diabetes mellitus, Confidence interval, Cohort study, Obesity, Environmental health, Endocrinology, Pathology
- MeSH
- humans, cardiovascular diseases, magnesium, diet, nutrition surveys, risk factors, cross-sectional studies, adult, united states, female, male, atherosclerosis, young adult, heart disease risk factors
7 authors
From CN
- Qingchun SongCentral South University; Second Xiangya Hospital of Central South University
- Long SongCentral South University; Second Xiangya Hospital of Central South University
- Hongduan LiuCentral South University; Second Xiangya Hospital of Central South University
- Haoyu TanCentral South University; Second Xiangya Hospital of Central South University
- Benli YangCentral South University; Second Xiangya Hospital of Central South University
- Chengming Fan · correspondingCentral South University; Second Xiangya Hospital of Central South University
Abstract
Background
Magnesium deficiency has been shown to accelerate atherosclerosis. We hypothesized that dietary magnesium intake at a young age is associated with future atherosclerotic lesions and cardiovascular risk in a large, nationally representative cohort of U.S. adults.
Methods
We included U.S. adults aged 20 to 34 years old from the National Health and Nutrition Examination Survey (NHANES) 2007 to 2018, a population-based cross-sectional study. Dietary magnesium intake was assessed using 24-hour diet recalls. Atherosclerotic lesions in the young adult population were predicted by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score that was based on age, sex, smoking status, lipids, blood pressure, and obesity. Information on cardiovascular disease (CVD) risk factors including hypertension, non-HDL-C dyslipidemia, and diabetes was also collected. We used multivariable logistic analysis models to test the association between magnesium intake levels and the PDAY score and CVD risk factors, respectively, after adjusting for several potential confounding factors.
Results
7,244 eligible participants were included in the analysis. The magnesium intake level was classified into three categories based on the tertile distribution in the population (i.e., ≤ 224, 225-340, and ≥ 341 mg/day). Compared with the lowest tertile, the multivariable-adjusted odds ratio (OR) and 95% confidence interval (95% CI) for the PDAY score were 0.83 (95% CI, 0.72 to 0.96) and 0.60 (95% CI, 0.49 to 0.74) in the second and the third tertiles of magnesium intake, respectively (P value for trend < 0.001), and there was a negative dose-response relationship (test for trend P value < 0.001). In addition, the highest dietary magnesium intake was significantly inverse associated with non-HDL-C dyslipidemia compared with the lowest magnesium intake (OR = 0.65; 95% CI, 0.46 to 0.91).
Conclusions
Dietary magnesium intake is inversely associated with the risk of future cardiovascular events assessed by the PDAY score and non-HDL-C dyslipidemia in young adulthood years.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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