Cardiac Rehabilitation for Prediabetes and Metabolic Syndrome Remission: Impact of Ultraprocessed Food-Intake Reduction and Time-Restricted Eating in the DIABEPIC-1 Study
Iglesies-Grau J, Dionne V, Latour É, Gayda M, Besnier F, Gagnon D, Debray A, Gagnon C, Tessier AJ, Paradis A, Klai C, Martin N, Pelletier V, Simard F, Nigam A, L'Allier PL, Juneau M, Bouabdallaoui N, Bherer L
CJC open · 5 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- University or hospital
- Université de Montréal
- University or hospital
- Institut de Cardiologie de Montréal
- Grants
- Institut de Cardiologie de Montréal (2022-3005)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-08-09 · CJC Open · vol. 6 · issue 11 · pp. 1411–1421
- Publisher
- Elsevier BV
- Cited
- 6 citations · more than 81% of similar papers · 1.3× the field average
- References
- 42 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Prediabetes, Medicine, Metabolic syndrome, Rehabilitation, Food intake, Reduction (mathematics), Internal medicine, Cardiology, Endocrinology, Diabetes mellitus, Physical therapy, Obesity, Type 2 diabetes
19 authors
From CA
- Josep Iglésies · correspondingMontreal Heart Institute; Université de Montréal
- Valérie DionneMontreal Heart Institute; Université de Montréal
- Élise LatourMontreal Heart Institute
- Mathieu GaydaMontreal Heart Institute; Université de Montréal
- Florent BesnierMontreal Heart Institute; Université de Montréal
- Daniel GagnonMontreal Heart Institute; Université de Montréal
Abstract
Background
Cardiac rehabilitation programs provide a valuable opportunity to promote the adoption of healthy lifestyle behaviors in patients with atherosclerotic cardiovascular diseases (ASCVDs) and metabolic comorbidities, including metabolic syndrome and prediabetes. However, strategies to reverse these conditions remain to be explored. The DIABEPIC-1 study aimed to assess the feasibility of an enhanced 6-month cardiac rehabilitation program for patients with ASCVD while investigating prediabetes and metabolic syndrome remission.
Methods
The study combined exercise training with a comprehensive nutritional intervention, emphasizing reduction in intake of ultraprocessed foods, adoption of a Mediterranean diet, and implementation of time-restricted eating. Baseline, 3-month, and 6-month assessments included segmental body-composition measurements, blood analysis, maximal exercise testing, nutritional diaries recorded with the Keenoa AI app, and lifestyle questionnaires. Remission criteria included a return to an HbA1c level of < 5.7%, and < 3 National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP-III) criteria for prediabetes and metabolic syndrome, respectively.
Results
A total of 36 participants were recruited. The study demonstrated completion rates of 94.4% at 3 months, and 88.9% at 6 months, and a mean compliance rate of 92.5% for planned clinical appointments. Significant reductions in waist circumference (-9.2 cm, P P < 0.001) were observed. Improvement in glycemic and lipid profiles, insulin-resistance marker levels, and liver health were noted. Participants enhanced their cardiorespiratory fitness, reduced their consumption of ultraprocessed food, and increased their adherence to the Mediterranean diet and time-restricted eating. Notably, 50% achieved prediabetes remission, and 70% with metabolic syndrome at baseline achieved remission.
Conclusions
The study demonstrates the possibility of enhancing cardiac rehabilitation with an intensive nutritional intervention, yielding clinically significant outcomes, including remission of key risk factors in a substantial number of ASCVD patients.
Clinical trial registration
ClinicalTrials.gov, NCT05459987.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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