Changes in choroidal thickness in pre-myopic children after repeated low-level red-light therapy and their role in predicting myopia prevention and controlling myopic shift
Xiang K, Wang J, Zhu Z, Zhang X, Zhang B, Chen J, Yang J, Du L, Ai Z, He X, Xu X
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2024-12-01 · Asia Pac J Ophthalmol (Phila) · vol. 14 · issue 2 · p. 100115
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 19 citations · more than 96% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinal Diseases and Treatments · Retinopathy of Prematurity Studies
- Keywords
- Ophthalmology, Medicine, Optometry
- MeSH
- choroid, humans, myopia, tomography, optical coherence, refraction, ocular, phototherapy, follow-up studies, visual acuity, child, female, male
11 authors
From CN, AU
- Kaidi XiangShanghai Eye Disease Prevention & Treatment Center
- Jingjing WangShanghai Eye Disease Prevention & Treatment Center
- Zhuoting ZhuThe University of Melbourne; Centre for Eye Research Australia
- Xinzi ZhangShanghai Eye Disease Prevention & Treatment Center; Shanghai Clinical Research Center
- Bo ZhangShanghai Eye Disease Prevention & Treatment Center
- Jun ChenShanghai Eye Disease Prevention & Treatment Center
Abstract
Purpose
To investigate longitudinal changes in choroidal thickness (ChT) after 1-year treatment of repeated low-level red-light (RLRL) and their predictive value in efficacy on myopia prevention and myopic shift among pre-myopic children.
Methods
278 pre-myopic (-0.50 D < spherical equivalent refraction, SER ≤ 0.50 D) participants were assigned to the RLRL group and control group randomly and evenly. The OCT, visual acuity, AL, SER and other parameters were measured before enrollment and every 3 months after intervention. The data from both eyes of the included participants were analyzed.
Results
A total of 463 eyes were analyzed. Due to the COVID-19 pandemic, 176 participants in the RLRL group had treatment interrupted. The continued RLRL group, interrupted RLRL group and control group were well balanced in baseline characteristics. In the continued and interrupted RLRL group, the average ChT increased significantly at 3-month visit (all P < 0.001) and the subfoveal ChT thickened evidently. The area under the curve (AUC) for the models including gender and 3-month change in ChT to predict satisfactory myopia prevention at 12 months was 0.983. The efficacy of the models that also used the combined indicators of baseline age, gender and the 3-month change in ChT to predict AL progression control over 12 months reached 0.944.
Conclusions
Continued RLRL intervention induced notable thickening of ChT in premyopic population, especially at the subfoveal sector. For participants received RLRL treatment, the 3-month change in ChT combined with other baseline factors have acceptable predictive discrimination of myopia prevention efficacy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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