Funded in part by International Nut and Dried Fruit Council
Effect of nut consumption on blood lipids: An updated systematic review and meta-analysis of randomized controlled trials
Nishi SK, Paz-Graniel I, Ni J, Valle-Hita C, Khoury N, Garcia-Gavilán JF, Babio N, Salas-Salvadó J
Nutrition, metabolism, and cardiovascular diseases : NMCD · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- Ministerio de Ciencia, Innovación y Universidades
- Government
- European Food Safety Authority
- Government
- European Commission
- Government
- Generalitat de Catalunya
- Government
- Ministerio de Educación, Cultura y Deporte
- Industry group
- International Nut and Dried Fruit Council
- Government
- Bundesministerium des Innern, für Bau und Heimat
- Government
- Canadian Institutes of Health Research
- Government
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Government
- Instituto de Salud Carlos III
- Government
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Government
- Government of Catalonia
- Grants
- Generalitat de Catalunya (2022 FI‐B100108); European Food Safety Authority (178\u2013182); Canadian Institutes of Health Research (171207_1); Agència de Gestió d'Ajuts Universitaris i de Recerca (2021FI_B 00145); European Food Safety Authority (13,15,16,183); Bundesministerium des Innern, für Bau und Heimat (29.9 kg/m2); Ministerio de Ciencia, Innovación y Universidades (FPU 20/00385)
Based on 12 listed funder(s).
Publication
- Published
- 2024-10-17 · Nutr Metab Cardiovasc Dis · vol. 35 · issue 5 · p. 103771
- Publisher
- Elsevier BV
- Cited
- 11 citations · more than 75% of similar papers · 1.2× the field average
- References
- 185 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Nuts composition and effects · Botany, Ecology, and Taxonomy Studies · Peanut Plant Research Studies
- Keywords
- Nut, Meta-analysis, Randomized controlled trial, Consumption (sociology), Medicine, Internal medicine, Engineering, Philosophy
- MeSH
- humans, nuts, lipids, nutritive value, adult, aged, middle aged, female, male, dyslipidemias, randomized controlled trials as topic, biomarkers, diet, healthy
8 authors
From ES
- Stephanie K. NishiInstitut de Recerca Biomèdica Catalunya Sud
- Indira Paz‐GranielInstitut de Recerca Biomèdica Catalunya Sud
- Jiaqi NiInstitut de Recerca Biomèdica Catalunya Sud
- Cristina Valle‐HitaInstitut de Recerca Biomèdica Catalunya Sud
- Nadine KhouryInstitut de Recerca Biomèdica Catalunya Sud
- Jesús Francisco García-GavilánInstitut de Recerca Biomèdica Catalunya Sud
Abstract
Aims
Nuts are nutrient-dense foods touted for their health-promoting effects, especially regarding cardiovascular health, yet inconsistencies in the literature remain in relation to their effect on blood lipids. Hence, a systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of nut intake on blood lipids.
Data synthesis
MEDLINE-PubMed and Cochrane databases were searched. 113 unique trials met eligibility criteria (n = 8060 adults with various health status) assessing the effect of a median daily dose of 45.5 g/d of nuts compared to a non-nut control on blood lipid outcomes met inclusion criteria. Overall, nut consumption resulted in moderate reductions in total cholesterol (mean difference, -0.14 mmol/L [95 % confidence interval, -0.18 to -0.10 mmol/L]) and LDL-C (-0.12 mmol/L [-0.14 to -0.09 mmol/L]), with small reductions in triglycerides (-0.05 mmol/L [-0.07 to -0.03 mmol/L]), TC:HDL-C (-0.11 [-0.16 to -0.06]), LDL-C:HDL-C (-0.19 [-0.24 to -0.12]), and apolipoprotein B (-0.04 g/L [-0.06 to -0.02 g/L]). There was no significant impact on HDL-cholesterol or other assessed measures. Certainty of evidence was high for apolipoprotein A, and generally moderate/low for all other outcomes. Sensitivity analysis did not change the evidence on the main outcomes. Significant effect modifications in subgroup analysis were shown for most of the lipid parameters assessed. None of these subgroup effects altered the evidence of heterogeneity for any primary outcome.
Conclusions
Current evidence provides a good indication that consuming nuts may advantageously affect blood lipids in adults with a mix of health status.
Prospero registration
PROSPERO identifier, CRD42022358688.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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