Increased magnesium intake does not mitigate MAFLD risk associated with magnesium deficiency
Peng H, Zhao M, Zhang Y, Guo Y, Zhao A
Scientific reports · 3 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Chongqing
- University or hospital
- Centre Scientifique et Technique du Bâtiment
- Government
- Special Funding for Postdoctoral Research Project of Chongqing
- Government
- Natural Science Foundation of Chongqing, China
- Government
- National Nature Science Foundation of China
- Grants
- Natural Science Foundation of Chongqing (CSTB2022NSCQ); National Natural Science Foundation of China (82102337)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-12-05 · Sci Rep · vol. 14 · issue 1 · p. 30386
- Publisher
- Nature Portfolio
- Cited
- 5 citations · more than 75% of similar papers · 1.1× the field average
- References
- 41 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Nutrition and Health in Aging
- Keywords
- Magnesium deficiency (plants), Magnesium, Medicine, Internal medicine, Endocrinology, Chemistry
- MeSH
- humans, fatty liver, magnesium deficiency, magnesium, risk factors, oxidative stress, adult, aged, middle aged, united states, female, male
5 authors
From CN
- Haiyang PengDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Minjie ZhaoDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Yuezhou ZhangDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Yaoyuan GuoChongqing Medical and Pharmaceutical College
- Andong Zhao · correspondingDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
Abstract
Serum magnesium cannot accurately assess magnesium deficiency. The association between magnesium deficiency and metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear. Selecting 3,377 participants in the United States, we assessed the degree of magnesium deficiency in the population using magnesium depletion score (MDS). Multinomial logistic regression assessed the association between magnesium deficiency and MAFLD. Subgroup analyses assessed the association between dietary magnesium intake and MAFLD under different magnesium deficiency statuses. Structural equation modeling (SEM) revealed mediation effects. Magnesium deficiency was associated with MAFLD (ORseverevs.none: 1.69, 95%CI: 1.16-2.46; p for trend < 0.001). Magnesium intake was negatively associated with MAFLD only in the subgroup without magnesium deficiency (p for trend < 0.01). Inflammation, oxidative stress, and aging significantly mediated the association between MDS and MAFLD (all p < 0.05). In American adults, magnesium deficiency assessed by MDS might be a risk factor for MAFLD, with inflammation, oxidative stress, and aging potentially being key mechanisms. Simply increasing magnesium intake would not mitigate MAFLD risk associated with magnesium deficiency. Correcting magnesium deficiency might prevent MAFLD.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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