Red Meat, Poultry, and Fish Consumption and the Risk of Liver Cancer: A Prospective Cohort Study of 0.5 Million Chinese Adults
Wang CR, Cai D, He K, Hu JJ, Dai X, Zhu Q, Zhong GC
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Natural Science Foundation of China (NSFC)
- Grants
- National Natural Science Foundation of China (82203391)
Based on 2 listed funder(s).
Publication
- Published
- 2024-12-23 · Cancer Epidemiol Biomarkers Prev · vol. 34 · issue 3 · pp. 412–419
- Publisher
- American Association for Cancer Research
- Cited
- 3 citations · more than 81% of similar papers · 1.1× the field average
- References
- 47 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact · Antioxidant Activity and Oxidative Stress
- Keywords
- Liver cancer, Medicine, Prospective cohort study, Epidemiology, Environmental health, Red meat, Fish <Actinopterygii>, Chinese population, Cohort study, Consumption (sociology), Population, Cancer, Internal medicine, Biology, Pathology, Fishery, Genotype, Gene, Genetics
- MeSH
- animals, poultry, fishes, humans, liver neoplasms, diet, incidence, risk factors, follow-up studies, prospective studies, adult, aged, middle aged, china, female, male, red meat, east asian people
7 authors
From CN
- Chun-Rui WangDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Dong CaiDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Kun HeDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Jie‐Jun HuDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Xin DaiDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Qian ZhuChongqing Public Health Medical Center; Chongqing Medical University
Abstract
Background
Epidemiological evidence on meat consumption and liver cancer risk is limited and inconclusive; moreover, no prospective study has been conducted to investigate this association in China. Hence, we performed this study to examine the association of red meat, poultry, and fish consumption with the risk of liver cancer in a Chinese population.
Methods
A total of 510,048 Chinese adults of ages 30 to 79 years were included and were followed up through December 31, 2016. Red meat, poultry, and fish consumption was evaluated using an interviewer-administered laptop-based questionnaire. HRs and 95% confidence intervals (CI) for liver cancer incidence were calculated using Cox regression.
Results
Over a mean follow-up of 9.94 years, 1,906 liver cancer cases were observed. Each 50 g/day increase in red meat (HR 0.72; 95% CI, 0.49-1.05), poultry (HR 0.93; 95% CI, 0.83-1.03), and fish (HR 0.95; 95% CI, 0.85-1.05) consumption was not associated with the risk of liver cancer in the whole study population; however, subgroup analysis revealed an inverse association with poultry consumption in rural residents but not in urban residents (Pinteraction = 0.046). The initial associations did not change materially in a series of sensitivity analyses.
Conclusions
Red meat and fish consumption is not associated with the risk of liver cancer in this Chinese population. The inverse association with poultry consumption in Chinese rural residents should be interpreted with caution.
Impact
This is the first prospective study examining the association between meat consumption and the risk of liver cancer in the Chinese population.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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