Legumes as a Substitute for Red and Processed Meat, Poultry or Fish, and the Risk of Non-Alcoholic Fatty Liver Disease in a Large Cohort
Langmann F, Ibsen DB, Johnston LW, Perez-Cornago A, Dahm CC
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- University or hospital
- Aarhus Universitet
- Nonprofit
- Diabetesforeningen
- University or hospital
- This study was funded by Aarhus University and the Steno Diabetes Center Aarhus. The Graduate School of Health, Aarhus University funded the salary of Fie Langmann. Access to data and data management was funded by the Steno Diabetes Center Aarhus. Daniel B. Ibsen was funded by the Independent Research Fund Denmark with grant number 1057-00016B and the Danish Diabetes Association. The funding agencies had no role in the design and conduct of the study; the collection, management, analysis and interpretation of the data; the preparation, review and approval of the manuscript, or the decision to publish the manuscript.
Based on 3 listed funder(s).
Publication
- Published
- 2024-12-30 · J Hum Nutr Diet · vol. 38 · issue 1 · p. e70004
- Publisher
- Wiley
- Cited
- 9 citations · more than 90% of similar papers · 2.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (hybrid journal) · OTHER-OA
- Research areas
- Liver Disease Diagnosis and Treatment · Nutritional Studies and Diet · Fatty Acid Research and Health
- Keywords
- Medicine, Fatty liver, Fish <Actinopterygii>, Red meat, Disease, Cohort, Alcoholic liver disease, Environmental health, Cohort study, Food science, Internal medicine, Fishery, Pathology
- MeSH
- animals, poultry, fishes, humans, fabaceae, diet, proportional hazards models, risk factors, cohort studies, meat, meat products, seafood, adult, aged, middle aged, female, male, non-alcoholic fatty liver disease, red meat, united kingdom
5 authors
From DK, IT
- Fie LangmannAarhus University
- Daniel Borch IbsenSteno Diabetes Centers; Aarhus University; Aarhus University Hospital; Steno Diabetes Center Aarhus
- Luke JohnstonSteno Diabetes Centers; Aarhus University Hospital; Steno Diabetes Center Aarhus
- Aurora Perez‐CornagoJoint Research Centre
- Christina Catherine Dahm · correspondingAarhus University
Abstract
Background
Dietary recommendations have globally shifted towards promoting the consumption of legumes as an environmentally friendly and healthy source of protein. This study investigated the replacement of red and processed meat, poultry or fish for equal amounts of legumes on the risk of non-alcoholic fatty liver disease (NAFLD).
Methods
UK Biobank participants who completed ≥ 2 dietary assessments and had complete covariate information were included in the analyses (N = 124,546). Information on dietary intake was collected using two to five 24-h dietary assessments. Incident cases of NAFLD were determined through linkage to the National Health Service registries. The rate of developing NAFLD when replacing 80 g/week of red and processed meat, poultry or fish with legumes was estimated using multivariable-adjusted Cox proportional hazards regression.
Results
During follow-up (median 10.49, IQR: 10.4-10.9 years), 1205 individuals developed NAFLD. Replacing 80 g/week of red and processed meat or poultry with legumes was associated with 4% and 3% lower rates of NAFLD, respectively (red and processed meat HR: 0.96, 95% CI: 0.94; 0.98; poultry HR: 0.97, 95% CI: 0.95; 0.99). Replacing 80 g/week of fish with legumes was not associated with NAFLD (fish HR: 0.98, 95% CI: 0.96; 1.00). Results did not change markedly after adjustment for BMI.
Conclusions
Consuming one serving of legumes weekly instead of red and processed meat or poultry was associated with a slightly lower rate of NAFLD, while consuming legumes instead of fish did not show an association with NAFLD. Further research in cohorts with higher legume consumption is needed to confirm these findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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