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Effect of Creatine Monohydrate Supplementation on Macro- and Microvascular Endothelial Function in Older Adults: A Pilot Study
Clarke HE, Akhavan NS, Behl TA, Ormsbee MJ, Hickner RC
Nutrients · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Nonprofit
- American College of Sports Medicine
- Nonprofit
- ACSM Foundation
- Government
- National Institutes of Health
- Government
- National Heart, Lung, and Blood Institute
- Company
- Dymatize Nutrition
- Company
- Dymatize Nutrition®
- Government
- NHLBI NIH HHS
- Unclassified
- Linda Grizzard Owens
- Nonprofit
- American College of Sports Medicine Foundation Doctoral Student Research Grant
- Grants
- National Heart, Lung, and Blood Institute (R15 HL113854)
Based on 9 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-12-27 · Nutrients · vol. 17 · issue 1 · p. 58
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 6 citations · more than 78% of similar papers · 1.3× the field average
- References
- 63 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Thermoregulation and physiological responses · Cardiovascular and exercise physiology
- Keywords
- Pulse wave velocity, Medicine, Malondialdehyde, Internal medicine, Crossover study, Endocrinology, Creatine, Placebo, Blood pressure, Oxidative stress
- MeSH
- endothelium, vascular, microcirculation, humans, creatine, lipoproteins, ldl, pilot projects, cross-over studies, double-blind method, vasodilation, dietary supplements, aged, middle aged, female, male, ankle brachial index, pulse wave analysis, biomarkers, biopterins
5 authors
From US, ZA
- Holly Elizabeth ClarkeFlorida State University
- Neda Sara AkhavanUniversity of Nevada, Las Vegas
- Taylor A. BehlFlagler College
- Michael J. OrmsbeeFlorida State University; University of KwaZulu-Natal
- Robert Charles Hickner · correspondingFlorida State University; University of KwaZulu-Natal
Abstract
Background/Objectives: A pilot study was conducted to investigate the effect of four weeks of creatine monohydrate (CrM) on vascular endothelial function in older adults. Methods: In a double-blind, randomized crossover trial, twelve sedentary, healthy older adults were allocated to either the CrM or placebo (PL) group for four weeks, at a dose of 4 × 5 g/day for 5 days, followed by 1 × 5 g/day for 23 days. Macrovascular function (flow-mediated dilation [FMD%], normalized FMD%, brachial-ankle pulse wave velocity [baPWV], pulse wave analysis [PWA]), microvascular function (microvascular reperfusion rate [% StO2/sec]), and biomarkers of vascular function (tetrahydrobiopterin [BH4], malondialdehyde [MDA], oxidized low-density lipoprotein [oxLDL], glucose, lipids) were assessed pre- and post-supplementation with a four-week washout period. Results: CrM significantly increased FMD% (pre-CrM, 7.68 ± 2.25%; post-CrM, 8.9 ± 1.99%; p -4 ± 1.03 × 10-4%/AUCSR; post-CrM, 3.42 × 10-4 ± 1.69 × 10-4%/AUCSR; p p p p Conclusions: These pilot data indicate that four weeks of CrM supplementation resulted in favorable effects on several indices of vascular function in older adults.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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