Association of whole grain food consumption with lung cancer risk: a prospective cohort study
Wang K, Zhao J, Yang D, Sun M, Wu Y, Zhou W
Cancer cell international · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- Chongqing University
- Government
- National Cancer Institute
- Government
- Chongqing Shapingba District Technological Innovation Project
- Government
- Chongqing Talent Plan
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-01-14 · Cancer Cell Int · vol. 25 · issue 1 · p. 14
- Publisher
- BioMed Central
- Cited
- 9 citations · more than 95% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Food composition and properties · Potato Plant Research · Wheat and Barley Genetics and Pathology
- Keywords
- Medicine, Prospective cohort study, Lung cancer, Whole grains, Association (psychology), Environmental health, Consumption (sociology), Cancer, Cohort study, Cohort, Oncology, Internal medicine, Food science, Biology, Psychology
6 authors
From CN, US
- Kanran Wang · correspondingChongqing University; Chongqing Cancer Hospital
- Junhan ZhaoHarvard University
- Dingyi YangChongqing University; Chongqing Cancer Hospital
- Mao SunChongqing University; Chongqing Cancer Hospital
- Yongzhong WuChongqing University; Chongqing Cancer Hospital
- Wei Zhou · correspondingChongqing University; Chongqing Cancer Hospital
Abstract
Background
Whether the intake of whole grain foods can protect against lung cancer is a long-standing question of considerable public health import, but the epidemiologic evidence has been limited. Therefore we aim to investigate the relationship between whole grain food consumption and lung cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.
Methods
Diet was assessed with a self-administered Diet History Questionnaire (DHQ) at baseline. All incident lung cancer cases were pathologically verified. Hazard ratios and 95% confidence intervals for lung cancer risk associated with whole grain food consumption were estimated by Cox proportional hazards regression.
Results
During a median follow-up of 12.2 years, a total of 1,706 incident lung cancer events occurred, including 1,473 (86.3%) cases of non-small cell lung cancer (NSCLC) and 233 (13.7%) of small cell lung cancer (SCLC). After multivariate adjustment, comparing the highest quarter of consumption of whole grain foods to the lowest quarter, a 16% lower rate (HR 0.84, 95% CI 0.73-0.98) of lung cancer risks and a 17% lower rate (HR 0.83, 95% CI 0.69-0.98) for NSCLC were found, but no significant difference was shown for SCLC (HR 0.95, 95% CI 0.63-1.44). These results were consistently observed after a large range of subgroup and sensitivity analyses. A linear dose-response pattern was shown for lung cancer, NSCLC, and SCLC (P for non-linearity > 0.05).
Conclusions
In this large prospective cohort study, whole grain food consumption was associated with reduced lung cancer and NSCLC. Our findings suggest a potential protective role of whole grain foods against lung cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.