Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture
Gao Y, Hu Y, Wang J, Liu C, Im H, Jin W, Zhu W, Ge W, Zhao G, Yao Q, Wang P, Zhang M, Niu X, He Q, Wang Q
NeuroImage · 25 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Education of the People's Republic of China
- Government
- Natural Science Foundation of Tianjin City
- University or hospital
- Guilin Medical University
- Government
- Natural Science Foundation of Tianjin-Science and Technology Correspondent Project
- Government
- Natural Science Foundation of Tianjin Science and Technology Correspondent Project
- Government
- Ministry of Education of the People's Republic of China
- Government
- Natural Science Foundation of Tianjin Municipality
- Grants
- National Natural Science Foundation of China (31972906); National Natural Science Foundation of China (32000786); Guilin Medical University (GKLBCN-202401-03); Natural Science Foundation of Tianjin-Science and Technology Correspondent Project (23JCYBJC00910)
Based on 8 listed funder(s).
Publication
- Published
- 2025-01-16 · Neuroimage · vol. 307 · p. 121029
- Publisher
- Elsevier BV
- Cited
- 40 citations · more than 99% of similar papers · 10.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 134 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Tryptophan and brain disorders · Functional Brain Connectivity Studies · Mental Health Research Topics
- Keywords
- short video addiction, social media addiction, dispositional envy, orbitofrontal cortex, cerebellum, dorsolateral prefrontal cortex, posterior cingulate cortex, temporal pole, spontaneous neuronal activity, gray matter volume, gene expression, excitatory and inhibitory neurons, representational similarity analysis, brain transcriptomics
- MeSH
- brain, cerebellum, prefrontal cortex, humans, magnetic resonance imaging, adolescent, adult, female, male, young adult, transcriptome, gray matter, internet addiction disorder
15 authors
From CN, US
- Yuanyuan GaoTianjin Normal University
- Ying HuTianjin Normal University
- Jinlian WangTianjin Normal University
- Chang LiuTianjin Normal University
- Hohjin Im
- Weipeng JinTianjin Huanhu Hospital
Abstract
Short video addiction (SVA) has emerged as a growing behavioral and social issue, driven by the widespread use of digital platforms that provide highly engaging, personalized, and brief video content. We investigated the neuroanatomical and functional substrates of SVA symptoms, alongside brain transcriptomic and cellular characteristics, using Inter-Subject Representational Similarity Analysis (IS-RSA) and transcriptomic approaches. Behaviorally, we found that dispositional envy was associated with SVA. Structurally, SVA was positively correlated with increased morphological volumes in the orbitofrontal cortex (OFC) and bilateral cerebellum. Functionally, the dorsolateral prefrontal cortex (DLPFC), posterior cingulate cortex (PCC), cerebellum, and temporal pole (TP) exhibited heightened spontaneous activity, which was positively correlated with SVA severity. Transcriptomic and cellular analyses also showed specific genes linked to gray matter volume (GMV) associated with SVA, with predominant expression in excitatory and inhibitory neurons. These genes showed distinct spatiotemporal expression patterns in the cerebellum during adolescence. This study offers a comprehensive framework integrating structural, functional, and neurochemical evidence to highlight the neural-transcriptomic underpinnings of SVA symptoms in a non-clinical population.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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