Impact of repeated low-level red-light therapy on axial length, refraction, and macular retinal blood flow density in adolescents with mild to moderate myopia
Ji M, Ba T, Li H, Wang D, Zhang G, Wang W
Photodiagnosis and photodynamic therapy · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2025-01-30 · Photodiagnosis Photodyn Ther · vol. 52 · p. 104499
- Publisher
- Elsevier BV
- Cited
- 5 citations · more than 91% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 27 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Retinopathy of Prematurity Studies
- Keywords
- Retinal, Ophthalmology, Refraction, Medicine, Blood flow, Optometry, Optics, Physics, Internal medicine
- MeSH
- retinal vessels, macula lutea, humans, myopia, refraction, ocular, photochemotherapy, retrospective studies, adolescent, child, female, male, axial length, eye
6 authors
From CN
- Meiqi Ji
- Teer BaInner Mongolia Medical University
- Huixia Li
- Dongxue Wang
- Guisen Zhang · corresponding
- Wei Wang · correspondingWeifang People's Hospital; Weifang Chinese Medicine Hospital
Abstract
Background
In order to evaluate the effectiveness of repeated low-level red-light (RLRL) therapy on stabilizing axial elongation and refractive changes in adolescents with mild to moderate myopia. In addition, we also examined whether RLRL therapy affects retinal blood flow density in the macular region, a factor previously unstudied in this context.
Methods
Conducted at a single clinical site, this retrospective, single-arm study followed participants over six months, with assessments at baseline, 1 month, 3 months, and 6 months. The primary outcomes included axial length and spherical equivalent refraction (SER) changes. Secondary assessments included retinal blood flow density (superficial and deep macular layers), white-to-white corneal diameter, central corneal thickness, intraocular pressure (IOP), corneal curvature, light sensitivity, and peripheral retinal thickness.
Results
There were 32 enrolled participants (mean age = 11.5 ± 1.72) in the current study. The spherical equivalent (SER) remained relatively stable over the first three months, but it significantly improved at six months, changing from -2.39 ± 2.21 D at baseline to -2.01 ± 2.12 D (P 0.05), with no significant changes over the six months. There were no obvious side effects following the treatment.
Conclusions
Low-energy red light therapy shows promise as a non-invasive approach for stabilizing myopia in adolescents, with no observed compromise to retinal blood flow density. Further longitudinal research is needed to validate these findings and support clinical recommendations for myopia management.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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