Synergistic effect of defocus incorporated multiple segment glasses and repeated low level red light therapy against myopia progression
Yang Y, Liu S, Gao W, Wang L, Liu N, Zhang S, Yang L, Cheng L
Scientific reports · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2025-02-01 · Sci Rep · vol. 15 · issue 1 · p. 3996
- Publisher
- Nature Portfolio
- Cited
- 13 citations · more than 98% of similar papers · 7.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 29 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Retinal Diseases and Treatments
- Keywords
- Ophthalmology, Medicine, Optometry, Computer science
- MeSH
- humans, myopia, disease progression, refraction, ocular, treatment outcome, phototherapy, follow-up studies, eyeglasses, adolescent, child, female, male, axial length, eye
8 authors
From CN, US
- Yan Fang YangShanxi Eye Hospital
- Sen LiuShanxi Eye Hospital
- Wenwen GaoShanxi Eye Hospital
- Lei WangShanxi Eye Hospital
- Na LiuShanxi Eye Hospital
- Shiying ZhangShanxi Eye Hospital
Abstract
Defocus incorporated multiple segment (DIMS) lenses and repeated low-level red-light (RLRL) are used to retard myopia progression. However, it is currently unknown if there is a synergistic effect of the two interventions. In the current study, 190 school-aged children with myopia (380 eyes) were studied for the change in axial length (AL) over nearly one year of follow-up. Of 380 eyes, 170 eyes wore DIMS lenses, 80 eyes had RLRL therapy, and 130 eyes had both interventions (DIMS_RLRL) for myopia control. AL changes were calculated at each follow-up visit by subtracting the baseline measurements and normalized to yearly changes in mm. AL changes as a primary outcome were analyzed in a generalized linear mixed model to compare effect sizes of myopia control among three interventions while adjusting for age, sex, baseline axial length, and follow-up length. Participants had a mean age of 9.84 ± 2.63 years old, mean AL of 24.49 ± 1.20 mm, mean SER of -2.90 ± 2.08 diopters, and mean follow-up time of 301 ± 91 days. By the end of the study, the adjusted mean yearly axial change with combination therapy was - 0.13 mm, -0.04 mm for the eyes with RLRL alone, and 0.16 mm for the eyes with DIMS lenses alone (p < 0.0001). Combination therapy of DIMS and RLRL has significantly greater effect size in controlling myopia progression than either RLRL alone (p = 0.0009) or DIMS alone (p < 0.0001).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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