Timing of magnesium supplementation in patients with nephrolithiasis: A randomized controlled trial
Sharbaugh AJ, Ayyash OM, Riley JM, Averch TD, Semins MJ
Clinical nephrology · 0 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2025-02-06 · Clin Nephrol · vol. 103 · issue 5 · pp. 312–317
- Publisher
- Dustri-Verlag
- Cited
- 1 citation · more than 63% of similar papers · 0.6× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Kidney Stones and Urolithiasis Treatments · Magnesium in Health and Disease · Biomedical Research and Pathophysiology
- Keywords
- Medicine, Randomized controlled trial, Magnesium, Nephrology, Internal medicine, Calcium supplementation, Calcium
- MeSH
- humans, hyperoxaluria, magnesium, calcium oxalate, citric acid, treatment outcome, fasting, drug administration schedule, prospective studies, pilot projects, time factors, dietary supplements, adult, middle aged, female, male, nephrolithiasis
5 authors
- Adam J. Sharbaugh
- Omar M. Ayyash
- Julie M. Riley
- Timothy D. Averch
- Michelle Jo Semins
Abstract
Background
Urinary magnesium plays an important role in the prevention of calcium oxalate stone formation, but the role of magnesium supplementation has yet to be clearly defined. We examined the urinary biochemistry of patients taking magnesium supplementation with meals versus while fasting.
Materials and methods
This was a single-institution, prospective, randomized controlled pilot study examining magnesium supplementation taken with meals versus while fasting in patients with a history of calcium oxalate stones and isolated hyperoxaluria. Patients were provided a controlled diet and randomized to take magnesium supplementation either fasting or with meals during a 7-day study period. A pre-intervention and post-intervention 24-hour urinalysis was completed for all patients.
Results
Eight patients were enrolled with 4 patients randomized to each arm of magnesium supplementation. Those taking magnesium supplementation with meals experienced a median decrease of 17.8 mg/d in urinary oxalate, increase of 33.6 mg/d in urinary magnesium, and increase of 134.8 mg/d in urinary citrate from the pre- to the post-intervention 24-hour urinalysis. Those taking supplementation while fasting experienced an average decrease of 8.5 mg/d in urinary oxalate, increase of 21.8 mg/d in urinary magnesium, and increase of 116.6 mg/d of urinary citrate.
Conclusion
Patients with a prior history of calcium oxalate stone formation and isolated hyperoxaluria who took magnesium supplementation with meals were found to have a more substantial improvement in urinary parameters on 24-hour urinalysis compared to those who took magnesium supplementation while fasting. Magnesium supplementation should be taken with meals if prescribed for the prevention of recurrent calcium oxalate nephrolithiasis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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